Actively Recruiting
Netherlands Cohort Study on Acute HIV Infection
Led by Prof. Jan Prins · Updated on 2023-02-15
183
Participants Needed
1
Research Sites
678 weeks
Total Duration
On this page
Sponsors
P
Prof. Jan Prins
Lead Sponsor
U
UMC Utrecht
Collaborating Sponsor
AI-Summary
What this Trial Is About
Investigation of the size, variability and localization of the (pro) viral reservoir and the properties of HIV-specific immune response related to "post-treatment viral remission' achievement and / or duration. In addition we will study the factors that determine latency in the different host cells, their sensitivity to induction of replication competent virus by various agents and the potential application of these agents in "post-treatment viral remission". This all will be studied in patients included during acute phase of the infection who start antiretroviral therapy immediately upon diagnosis.
CONDITIONS
Official Title
Netherlands Cohort Study on Acute HIV Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent for sample storage and genetic testing
- Provide separate written consent for invasive procedures like leukapheresis, biopsies, lymph node excision, and lumbar puncture
- Be 18 years of age or older
- Have an acute HIV-1 infection defined by Fiebig stages I to IV, or meet specific criteria for stages V and VI
- Female participants must agree to use effective contraception
You will not qualify if you...
- Have contraindications to the proposed cART treatment, such as impaired kidney function
- Have a mental disorder that could interfere with adherence to treatment or study participation
- Use immunosuppressive medication or have other diseases causing immune deficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105 AZ
Actively Recruiting
Research Team
P
Pien van Paassen, MD
CONTACT
G
Godelieve de Bree, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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