Actively Recruiting
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
Led by Central Institute of Mental Health, Mannheim · Updated on 2025-04-29
100
Participants Needed
2
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are: What are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to: * alcohol craving? * alcohol use? * their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior? Participants will: * be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test * be exposed to their favorite drink in a bar lab environment * be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing * conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details on social interactions, health behavior and coping strategies using ecological momentary assessment tools.
CONDITIONS
Official Title
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 16 and 65 years
- Meeting at least 2 criteria of alcohol use disorder according to DSM-5 without need for therapeutic intervention
- Fluent in German
- Able to understand study procedures and provide informed consent
- Willingness to use a study smartphone
You will not qualify if you...
- Current use of drugs or medications affecting central nervous system or glucocorticoid system
- Contraindications for magnetic resonance imaging
- Medical history of bipolar disorder, psychotic disorder, schizophrenia spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis
- Medical history of severe head injury, severe central nervous system disorders, or severe somatic disorders like liver cirrhosis
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Central Institute of Mental Health
Mannheim, Baden-Wurttemberg, Germany, 68159
Actively Recruiting
2
Central Institute of Mental Health
Mannheim, Germany, 68159
Actively Recruiting
Research Team
P
Patrick Bach, MD, PhD
CONTACT
J
Judith Zaiser
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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