Actively Recruiting
Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)
Led by Womack Army Medical Center · Updated on 2026-04-22
180
Participants Needed
2
Research Sites
87 weeks
Total Duration
On this page
Sponsors
W
Womack Army Medical Center
Lead Sponsor
U
University of Kentucky
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to examine the effectiveness of a novel ankle rehabilitation protocol on improving clinical and health outcomes in physically active individuals with chronic ankle instability (CAI). Our central hypothesis is NATION, a novel rehabilitation intervention that includes neurocognitive tasks, will improve overall health and function, and reduce lower extremity musculoskeletal injury in physically active individuals with CAI.
CONDITIONS
Official Title
Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physically active and engage in regular exercise/training
- 18-44 years old (accounts for 86% of the individuals deployed in recent military conflicts)
- Answer "yes" to Question 1 (i.e., have you ever sprained an ankle?) on the Ankle Instability Instrument
- Answer "yes" to any four of the remaining Ankle Instability Instrument questions
- Score <24 on the Cumberland Ankle Instability Tool
- Report at least two episodes of the ankle "giving way" in the last six months
- Access to a functional email address and internet for completion of health and Service member outcomes
- Ability to provide informed consent
You will not qualify if you...
- Unable to read or comprehend the English language
- An ankle sprain within the last six (≤6) weeks that resulted in altered or missed physical activity for one or more (≥1) consecutive days
- History of ankle surgery
- History of lower extremity fracture in the last year or history of fracture that required fixation
- Any peripheral neuropathies or other health conditions/current musculoskeletal injuries that may influence balance
- Pregnant females (will be eligible for participation in the study after delivery of the baby and medical clearance by a qualified and licensed healthcare provider)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
University of Kentucky
Lexington, Kentucky, United States, 40506
Actively Recruiting
2
Womack Army Medical Center
Fort Bragg, North Carolina, United States, 28310
Actively Recruiting
Research Team
M
Megan H. Roach, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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