Actively Recruiting
Optimization of Neurophysiologic Biomarkers for Rehabilitation Interventions in Veterans With Chronic Psychosis
Led by VA Office of Research and Development · Updated on 2025-10-09
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to improve cognitive rehabilitation for Veterans living with chronic psychosis, including schizophrenia and related disorders. Cognitive symptoms in schizophrenia affect daily functioning and are not fully addressed by standard antipsychotic treatments. The study seeks to develop brain-based tools to identify which Veterans might benefit most from therapies targeting cognitive function, potentially leading to better life quality and functional outcomes. The study is observational and involves Veterans with chronic psychotic disorders as well as healthy Veterans in good general health. There are two phases: Phase 1 focuses on optimizing neurophysiologic biomarkers using electroencephalography (EEG) during two test visits spaced 1 to 2 weeks apart. Phase 2 validates these biomarkers by assessing their changes before and after one hour of computerized cognitive training in Veterans with schizophrenia. Participants will undergo detailed neurophysiological, clinical, cognitive, and functional assessments. Researchers will measure the reliability of brain biomarkers over one week, evaluate cognitive training performance, and assess symptoms and quality of life. The study includes screening for eligibility, multiple assessments, and uses EEG to record brain activity. Participation lasts through both phases with repeated evaluations to understand how brain measures relate to rehabilitation outcomes.
CONDITIONS
Brief Title
Neurophysiologic Biomarkers for Cognitive Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a DSM-5 diagnosis of a chronic psychotic disorder (e.g., schizophrenia, schizoaffective disorder, or delusional disorder) or be in good general mental and physical health without active mental health conditions
- Fluent in spoken and written English
- No impairment in hearing or vision
You will not qualify if you...
- Active substance use other than cannabis within the last 30 days based on self-report or urine toxicology
- History of significant medical or neurological illness or intellectual disability
- Inability to comprehend or provide informed consent
- For healthy comparison subjects: past or present diagnosis of schizophrenia, schizoaffective disorder, or other chronic psychotic disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to 2 weeks
Participants undergo comprehensive neurophysiological, clinical, cognitive, and functional assessments to identify neurophysiologic biomarkers.
2 visits (in-person) approximately 1 to 2 weeks apart
Duration - Single day
Participants with chronic psychotic disorders receive 1 hour of cognitive training with neurophysiologic measures assessed before and after to evaluate neural system target engagement.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161-0002
Actively Recruiting
Research Team
J
Juan Molina, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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