The spectrum of structural brain changes in schizophrenia: age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates.
E C Johnstone, D G Owens, G M Bydder...
https://pubmed.ncbi.nlm.nih.gov/2727213Completed
Led by National Institute of Mental Health (NIMH) · Updated on 2017-07-02
4300
Participants Needed
7
Research Sites
N/A
Total Duration
This study will allow researchers to use various types of tests to evaluate cognitive and sensory functions. These tests, referred to as "batteries" will evaluate attention, executive functions, general intellectual functioning, language, memory, motor functions, orientation, personality, selected sensory and perceptual functions, vigilance (alertness), and visual-spatial functions. Children and adult patient will receive different test batteries. The goals of this research study are to; 1. Create descriptions based on the performance of each patient on the test batteries. Then use this information to relate patient behavior to their neurophysiological, neuroradiological, and biochemical descriptions. 2. Define subgroups of patients based on their neurobehavior in order to decrease the variability of psychiatric diagnoses, treatments, and prognoses.
CONDITIONS
Neuropsychological Evaluation of Psychiatric and Neurological Patients
You may qualify if you...
Patients.
Normal volunteers.
EXCLUSION CRITERIA:
Subjects over 95 years of age.
Subjects with a history of alcohol or drug abuse, psychopathology, or central nervous system pathology, other than that which defines group membership, may be excluded.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Total: 7 locations
1
Childrens National Medical Center
Washington D.C., District of Columbia, United States
Status Unknown
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Status Unknown
3
Henry Ford Health Systems
Detroit, Michigan, United States, 48202
Status Unknown
4
Mt. Sinai Medical Center
New York, New York, United States, 10029-0574
Status Unknown
5
Columbia University
New York, New York, United States, 10032-3784
Status Unknown
6
Genethon
Every Cedex, France
Status Unknown
7
Mosco Research Institute of Psychiatry
Moscow, Russia
Status Unknown
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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E C Johnstone, D G Owens, G M Bydder...
https://pubmed.ncbi.nlm.nih.gov/2727213