Study on How Nighttime Light and Eating Patterns Affect Your Metabolism and Sleep Health

What this Trial Is About

Researchers are investigating how different patterns of light exposure and timing of food intake affect metabolism when sleep is reduced. This randomized, in-lab, cross-over trial focuses on sleep restriction and circadian rhythm alignment to understand impacts on insulin sensitivity and internal biological clocks. The study includes adults aged 18 to 35 years with regular sleep habits and healthy body weight to explore the interaction between sleep, nutrition, and circadian health. Participants will complete three study arms in different orders, each involving 5 nights of sleep restriction under distinct conditions normal alignment of central and peripheral clocks, misalignment of the central clock by nighttime light exposure, and misalignment of peripheral clocks by shifting food intake to nighttime. Each arm is followed by a detailed assessment of 24-hour biological rhythms and an intravenous glucose tolerance test. Before enrollment, participants undergo sleep disorder screening and a 2-week baseline monitoring period. The study lasts about 4 to 6 months with 6 to 8 in-person visits, including three overnight stays. During the study, participants will complete surveys, medical tests, and overnight clinic visits to measure insulin sensitivity and internal circadian misalignment using specific biomarkers. Researchers will monitor sleep patterns, light exposure, and eating schedules closely. The study tracks how changes in these factors influence metabolism and biological rhythms, aiming to provide insights into the effects of sleep deprivation combined with lifestyle changes. Safety and adherence are monitored throughout the trial period.

Nighttime Synchrony of Your Nutrition and Circadian Health