Actively Recruiting
Normobaric Oxygen in AIS Transferred for EVT
Led by Capital Medical University · Updated on 2025-12-11
1500
Participants Needed
112
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to estimate the efficacy and safety of NBO on 3-month functional outcome after acute ischemic stroke
CONDITIONS
Official Title
Normobaric Oxygen in AIS Transferred for EVT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 18 years old
- Signs and symptoms consistent with a new acute stroke, with low possibility of stroke mimics
- No prior stroke in the last 3 months
- Time from stroke onset to randomization within 9 hours
- Baseline NIHSS score of 6 or more with specific intracranial occlusions confirmed by imaging or hyperdense MCA sign on CT, or NIHSS score 12 or more
- NIHSS score of 0 or 1 in level of consciousness section
- No significant pre-stroke disability (pre-stroke mRS 0-1)
- ASPECTS score at least 6 on non-contrast CT
- Planned transfer to EVT-capable hospital for EVT
- Signed informed consent from patient or legally authorized representative
You will not qualify if you...
- History of severe chronic obstructive pulmonary disease (FEV1 less than 1.0), NYHA Heart Failure Class III or IV, acute pulmonary infection or aspiration pneumonia
- Respiratory rate less than or equal to 10 or greater than or equal to 30 breaths per minute
- Oxygen dependence at baseline to maintain SaO2 above 95% or intubation at baseline
- Seizure at stroke onset
- Symptoms of vomiting, severe headache, or unconsciousness
- Rapidly improving neurological deficits or transient ischemic attack prior to consent
- Signs or symptoms of subarachnoid hemorrhage, even if CT is normal
- Evidence of intracranial tumor (except small meningioma) or arteriovenous malformation
- Woman of childbearing potential known to be pregnant or with positive pregnancy test
- Life expectancy less than 90 days due to comorbidity
- Unlikely to complete 90-day follow-up
- Participation in another clinical treatment trial within prior 30 days
- Receiving other cerebral protective agents
- Evidence of acute intracranial hemorrhage on CT or MRI
- Significant mass effect with midline shift on imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 112 locations
1
Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
2
Fujian Medical University First Affiliated Hospital
Fuzhou, Fujian, China
Actively Recruiting
3
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
Actively Recruiting
4
Fujian Minhou County Hospital
Fuzhou, Fujian, China
Actively Recruiting
5
Fuqing Hospital
Fuzhou, Fujian, China
Actively Recruiting
6
Fuqing Second Hospital
Fuzhou, Fujian, China
Actively Recruiting
7
Fuzhou Changle District People's Hospital
Fuzhou, Fujian, China
Actively Recruiting
8
Fuzhou Traditional Chinese Medicine Hospital
Fuzhou, Fujian, China
Actively Recruiting
9
Lianjiang County General Hospital
Fuzhou, Fujian, China
Actively Recruiting
10
Luoyuan County Hospital
Fuzhou, Fujian, China
Actively Recruiting
11
Minqing County General Hospital
Fuzhou, Fujian, China
Actively Recruiting
12
Yongtai County Hospital
Fuzhou, Fujian, China
Actively Recruiting
13
Gutian County Hospital
Ningde, Fujian, China
Actively Recruiting
14
Putian Hanjiang District Hospital
Putian, Fujian, China
Actively Recruiting
15
Dongshan County Hospital
Zhangzhou, Fujian, China
Actively Recruiting
16
Nanjing County Hospital
Zhangzhou, Fujian, China
Actively Recruiting
17
Pinghe County Hospital
Zhangzhou, Fujian, China
Actively Recruiting
18
Xiage Health Center
Zhangzhou, Fujian, China
Actively Recruiting
19
Yunxiao County Hospital
Zhangzhou, Fujian, China
Actively Recruiting
20
Yunxiao County Traditional Chinese Medicine Hospital
Zhangzhou, Fujian, China
Actively Recruiting
21
Zhangpu County Hospital
Zhangzhou, Fujian, China
Actively Recruiting
22
Zhangpu County Traditional Chinese Medicine Hospital
Zhangzhou, Fujian, China
Actively Recruiting
23
Zhangzhou Changtai District Hospital
Zhangzhou, Fujian, China
Actively Recruiting
24
Zhangzhou Fifth Hospital
Zhangzhou, Fujian, China
Actively Recruiting
25
Zhangzhou Gulei Port Economic Development Zone First Hospital
Zhangzhou, Fujian, China
Actively Recruiting
26
Zhangzhou Hospital Headquarters (High-Tech Campus)
Zhangzhou, Fujian, China
Actively Recruiting
27
Zhangzhou Hospital
Zhangzhou, Fujian, China
Actively Recruiting
28
Zhangzhou Second Hospital
Zhangzhou, Fujian, China
Actively Recruiting
29
Zhao'an County Hospital
Zhangzhou, Fujian, China
Actively Recruiting
30
Guangzhou Development District Hospital
Guangzhou, Guangdong, China
Actively Recruiting
31
Guangzhou He Xian Memorial Hospital
Guangzhou, Guangdong, China
Actively Recruiting
32
Jinan University First Affiliated Hospital
Guangzhou, Guangdong, China
Actively Recruiting
33
Yifeng County People's Hospital
Guangzhou, Guangdong, China
Actively Recruiting
34
Fuchuan Yao Autonomous County Ethnic Medicine Hospital
Hezhou, Guangxi, China
Actively Recruiting
35
Hezhou Traditional Chinese Medicine Hospital
Hezhou, Guangxi, China
Actively Recruiting
36
Zhaoping County People's Hospital
Hezhou, Guangxi, China
Actively Recruiting
37
Cangzhou Central Hospital
Cangzhou, Hebei, China
Actively Recruiting
38
Dongguang County People's Hospital
Cangzhou, Hebei, China
Actively Recruiting
39
Xianxian Traditional Chinese Medicine Hospital
Cangzhou, Hebei, China
Actively Recruiting
40
Daming County Traditional Chinese Medicine Hospital
Handan, Hebei, China
Actively Recruiting
41
Handan Central Hospital (East Campus)
Handan, Hebei, China
Actively Recruiting
42
Handan Fourth Hospital
Handan, Hebei, China
Actively Recruiting
43
Linzhang County People's Hospital
Handan, Hebei, China
Actively Recruiting
44
Quzhou County Hospital
Handan, Hebei, China
Actively Recruiting
45
Linkou County People's Hospital
Mudanjiang, Heilongjiang, China
Actively Recruiting
46
Mudanjiang Second People's Hospital
Mudanjiang, Heilongjiang, China
Actively Recruiting
47
Luoyang Central Hospital
Luoyang, Henan, China
Actively Recruiting
48
Song County People's Hospital
Luoyang, Henan, China
Actively Recruiting
49
Xin'an County People's Hospital
Luoyang, Henan, China
Actively Recruiting
50
Yichuan County People's Hospital
Luoyang, Henan, China
Actively Recruiting
51
Yima People's Hospital
Yima, Henan, China
Actively Recruiting
52
Yimei General Hospital
Yima, Henan, China
Actively Recruiting
53
Danchuan County Traditional Chinese Medicine Hospital
Zhoukou, Henan, China
Actively Recruiting
54
Luyi Zhenyuan Hospital
Zhoukou, Henan, China
Actively Recruiting
55
Shenqiu County People's Hospital
Zhoukou, Henan, China
Actively Recruiting
56
Zhoukou Central Hospital
Zhoukou, Henan, China
Actively Recruiting
57
Danchuan Central Hospital
Zhoukou, Hennan, China
Actively Recruiting
58
Hubei Minzu University Affiliated Minzu Hospital
Enshi, Hubei, China
Actively Recruiting
59
Huangmei County People's Hospital
Huanggang, Hubei, China
Actively Recruiting
60
Lichuan Traditional Chinese Medicine Hospital
Lichuan, Hubei, China
Actively Recruiting
61
Dexing People's Hospital
Dexing, Jiangxi, China
Actively Recruiting
62
Guangchang County People's Hospital
Fuzhou, Jiangxi, China
Actively Recruiting
63
Jinxi County People's Hospital
Fuzhou, Jiangxi, China
Actively Recruiting
64
Zixi County People's Hospital
Fuzhou, Jiangxi, China
Actively Recruiting
65
Dean County People's Hospital
Jiujiang, Jiangxi, China
Actively Recruiting
66
Dean County Traditional Chinese Medicine Hospital
Jiujiang, Jiangxi, China
Actively Recruiting
67
Hukou County People's Hospital
Jiujiang, Jiangxi, China
Actively Recruiting
68
Jiujiang First People's Hospital
Jiujiang, Jiangxi, China
Actively Recruiting
69
Pengze County People's Hospital
Jiujiang, Jiangxi, China
Actively Recruiting
70
Xiajiang County People's Hospital
Ji’an, Jiangxi, China
Actively Recruiting
71
Xingan County People's Hospital
Ji’an, Jiangxi, China
Actively Recruiting
72
Yongfeng County Traditional Chinese Medicine Hospital
Ji’an, Jiangxi, China
Actively Recruiting
73
Lushan People's Hospital
Lushancun, Jiangxi, China
Actively Recruiting
74
Anyi County People's Hospital
Nanchang, Jiangxi, China
Actively Recruiting
75
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, China
Actively Recruiting
76
Xinjian District People's Hospital
Nanchang, Jiangxi, China
Actively Recruiting
77
Poyang County People's Hospital
Shangrao, Jiangxi, China
Actively Recruiting
78
Wannian County People's Hospital
Shangrao, Jiangxi, China
Actively Recruiting
79
Fengxin County People's Hospital
Yichun, Jiangxi, China
Actively Recruiting
80
Shanggao County People's Hospital
Yichun, Jiangxi, China
Actively Recruiting
81
Yujiang District People's Hospital
Yingtan, Jiangxi, China
Actively Recruiting
82
Zhangshu People's Hospital
Zhangshu, Jiangxi, China
Actively Recruiting
83
Baoji High-Tech Hospital
Baoji, Shaanxi, China
Actively Recruiting
84
Caijiapo Hospital
Baoji, Shaanxi, China
Actively Recruiting
85
Longxian People's Hospital
Baoji, Shaanxi, China
Actively Recruiting
86
Meixian Traditional Chinese Medicine Hospital
Baoji, Shaanxi, China
Not Yet Recruiting
87
Liaocheng People's Hospital
Liaocheng, Shandong, China
Actively Recruiting
88
Feicheng Hospital of Shandong Yiyang Health Group
Tai’an, Shandong, China
Actively Recruiting
89
Jincheng First People's Hospital
Jinzhong, Shanxi, China
Actively Recruiting
90
Xiyang County People's Hospital
Jinzhong, Shanxi, China
Actively Recruiting
91
Wenshui County People's Hospital
Lüliang, Shanxi, China
Actively Recruiting
92
Shanxi Provincial People's Hospital
Taiyuan, Shanxi, China
Actively Recruiting
93
Binchuan County People's Hospital
Dali, Yunnan, China
Actively Recruiting
94
Binchuan County Traditional Chinese Medicine Hospital
Dali, Yunnan, China
Actively Recruiting
95
Dali Prefecture People's Hospital
Dali, Yunnan, China
Actively Recruiting
96
Heqing County People's Hospital
Dali, Yunnan, China
Actively Recruiting
97
Jianchuan County People's Hospital
Dali, Yunnan, China
Actively Recruiting
98
Midu County People's Hospital
Dali, Yunnan, China
Actively Recruiting
99
Nanjian Yi Autonomous County People's Hospital
Dali, Yunnan, China
Actively Recruiting
100
Yangbi County People's Hospital
Dali, Yunnan, China
Actively Recruiting
101
Yongping County People's Hospital
Dali, Yunnan, China
Actively Recruiting
102
Chenggong District People's Hospital
Kunming, Yunnan, China
Actively Recruiting
103
Jinning District People's Hospital
Kunming, Yunnan, China
Actively Recruiting
104
Kunming Medical University Yan'an Hospital
Kunming, Yunnan, China
Actively Recruiting
105
Songming County People's Hospital
Kunming, Yunnan, China
Actively Recruiting
106
Yiliang First People's Hospital
Kunming, Yunnan, China
Actively Recruiting
107
Yunnan Provincial First People's Hospital
Kunming, Yunnan, China
Actively Recruiting
108
The First People's Hospital of Qujing
Qujing, Yunnan, China, 655000
Actively Recruiting
109
Fuyuan County People's Hospital
Qujing, Yunnan, China
Actively Recruiting
110
Shizong County People's Hospital
Qujing, Yunnan, China
Actively Recruiting
111
Xuanwei First People's Hospital
Xuanwei, Yunnan, China
Actively Recruiting
112
Yuxi Zhongshan Hospital
Yuxi, Yunnan, China
Actively Recruiting
Research Team
L
Lan Liu, PhD
CONTACT
W
Wenbo Hu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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