Actively Recruiting
Observational Cohort Study of Chronic Viral Infection in the Central Nervous System
Led by Peking Union Medical College Hospital · Updated on 2026-04-06
66
Participants Needed
1
Research Sites
400 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research team intends to conduct a real-world cohort study of chronic CNS viral infections represented by PML, to evaluate whether administration of immune checkpoint inhibitors improves long-term outcomes in this patient population.Patients with prior follow-up will be enrolled into a retrospective/prospective ambidirectional cohort, and newly diagnosed patients will be enrolled into a prospective cohort.
CONDITIONS
Official Title
Observational Cohort Study of Chronic Viral Infection in the Central Nervous System
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 14 years old
- Confirmed diagnosis of chronic viral infection of the central nervous system
- Diagnosis of Progressive Multifocal Leukoencephalopathy (PML) meeting neuropathological or clinical+imaging+CSF criteria according to 2013 American Academy of Neurology guidelines
- Confirmation of diagnosis by two independent physicians from the Encephalitis Professional Group, Peking Union Medical College Hospital
- Signed informed consent
You will not qualify if you...
- Lumbar puncture contraindications preventing cerebrospinal fluid collection
- Virus detection in cerebrospinal fluid does not explain clinical symptoms as judged by doctor and researcher
- Inability to complete one-year follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
S
Siyuan Fan
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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