Actively Recruiting
Central Nervous System Chronic Viral Infections: A Cohort Study
Led by Peking Union Medical College Hospital · Updated on 2026-04-06
66
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a real-world observational cohort study to understand chronic viral infections in the central nervous system (CNS), such as Progressive Multifocal Leukoencephalopathy (PML). The study aims to evaluate whether immune checkpoint inhibitors, a type of drug, improve long-term outcomes for patients with these infections. Both patients with existing follow-up data and newly diagnosed patients will be enrolled to gather comprehensive information. Participants will be grouped into two cohorts: an ambidirectional cohort for those with prior follow-up data and a prospective cohort for newly diagnosed cases. The study involves monitoring patients over time without assigning treatments, focusing on observing their health and response to any use of immune checkpoint inhibitors. Participants will be followed for at least one year after disease onset, with regular assessments including neurological function tests using the Modified Rankin Scale (mRS), neuroimaging scans, and cerebrospinal fluid tests to detect viral DNA. Evaluations occur at one month, then every three months, to measure symptoms and neurological changes. This comprehensive monitoring helps researchers understand disease progress and treatment impact over time.
CONDITIONS
Brief Title
Observational Cohort Study of Chronic Viral Infection in the Central Nervous System
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 14 years old.
- Confirmed diagnosis of chronic viral infection of the central nervous system.
- Signed informed consent.
- Diagnosis of Progressive Multifocal Leukoencephalopathy (PML) meets neuropathological or clinical, imaging, and cerebrospinal fluid criteria as per 2013 American Academy of Neurology guidelines.
- Diagnosis of other chronic CNS viral infections confirmed by clinical signs and viral DNA detection in cerebrospinal fluid.
- Diagnosis confirmed independently by two physicians from the Encephalitis Professional Group at Peking Union Medical College Hospital with consensus.
You will not qualify if you...
- Lumbar puncture contraindications preventing cerebrospinal fluid collection.
- Clinical symptoms not explained by viral detection in cerebrospinal fluid as judged by physician.
- Inability to complete one-year follow-up.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 year (±3 months)
Participants with chronic viral infections of the central nervous system are observed over time to assess neurological and imaging outcomes.
Visits at 1 month after onset and every 3 months within 1 year
Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
S
Siyuan Fan
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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