Observational Cohort Study on Gastric Cancer Risk in Adults 40 and Older with High-Risk Helicobacter Pylori Genetic Variants

What this Trial Is About

Researchers are conducting a prospective observational cohort study to compare the incidence of gastric cancer and the progression of gastric precancerous lesions among groups with different Helicobacter pylori Hp genetic subtypes. The study focuses on adults aged 40 and older who have a baseline negative gastric endoscopy and are either carriers of high-risk Hp SNP subtypes, non-high-risk subtypes, or are Hp negative. The goal is to understand how these genetic differences impact gastric cancer risk over time. Participants are followed prospectively in three groups those who are Hp positive with high-risk SNP subtypes, those Hp positive with non-high-risk SNP subtypes, and those who are Hp negative. The study does not involve any treatment but monitors the natural progression of gastric conditions associated with these groups. Follow-up assessments occur over a period of up to 10 years, with primary and secondary outcomes measured at 3, 5, and 10 years. During the study, participants undergo baseline and follow-up examinations to monitor the incidence of gastric cancer and the development of precancerous lesions such as atrophic gastritis and intestinal metaplasia. Researchers also examine how factors like age, gender, diet, smoking, alcohol use, and family history might interact with Hp genetic risk. The primary outcome focuses on the difference in gastric cancer incidence among the groups during a 3-year follow-up, while secondary outcomes consider longer-term incidence and lesion progression. Participants safety and ability to continue in the study are monitored throughout the follow-up period.

An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori