Observing Adults With Desmoid-Type Fibromatosis Through Active Monitoring and Imaging

What this Trial Is About

Researchers are observing people with desmoid-type fibromatosis, a condition involving abnormal growth of fibrous tissue, to understand its progression over a period of at least one month. The study includes individuals newly diagnosed or with newly recurrent disease, aiming to monitor the condition without immediate treatment intervention. This observational study is sponsored by Memorial Sloan Kettering Cancer Center and focuses on tracking disease changes over time. Participants will undergo cross-sectional imaging using MRI with gadolinium contrast as the preferred method. For those unable to have MRI, CT scans with intravenous contrast will be used instead. The study involves active observation, with imaging assessments carried out to measure tumor size and progression. This approach allows researchers to evaluate the natural course of desmoid fibromatosis while participants are managed without systemic treatment. During the study, participants will have baseline and follow-up imaging scans to monitor tumor size and disease progression. Researchers will assess progression-free survival at 12 months as the primary outcome. Participants must be able to undergo imaging tests and provide informed consent. The study will monitor safety and disease status throughout the observation period, which may extend beyond the initial month based on clinical follow-up and imaging results.

Observing People With Desmoid-Type Fibromatosis