Actively Recruiting
Optimal Time for Reperfusion in Acute Pulmonary Embolism
Led by Azienda ULSS 8 Berica · Updated on 2026-03-03
500
Participants Needed
7
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality worldwide. Current guidelines recommend early reperfusion for high-risk and intermediate-high-risk PE, yet systemic thrombolysis and percutaneous therapies are frequently underutilized, and no specific timing for reperfusion is defined, unlike in acute myocardial infarction or ischemic stroke. As most PE-related in-hospital deaths occur within the first hours and thrombus composition changes over time, defining an optimal reperfusion time window may improve survival and prevent hemodynamic deterioration. We therefore propose a national, multicenter, prospective observational study to evaluate the prognostic impact of reperfusion timing, using systemic thrombolysis or catheter-directed therapies, on in-hospital mortality and haemorrhagic or cardiovascular complications.
CONDITIONS
Official Title
Optimal Time for Reperfusion in Acute Pulmonary Embolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63; 18 years
- Diagnosis of intermediate-high or high pulmonary embolism confirmed by CT pulmonary angiography, pulmonary angiography, or echocardiography
- Classified as high-risk or intermediate-high-risk according to 2019 European Society of Cardiology guidelines
- Provided informed consent for processing personal data
You will not qualify if you...
- Age < 18 years
- Diagnosis of acute high-risk or intermediate-high-risk pulmonary embolism excluded
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
UO Unità di Cure Intensive Cardiologiche e Cardiologia 1, Ospedale Niguarda, Milano
Milan, Milano, Italy, 20162
Actively Recruiting
2
UOC di Cardiologia, Ospedali Riuniti Padova Sud, Monselice, Italia
Monselice, Padova, Italy, 35043
Actively Recruiting
3
IRCCS Policlinico San Matteo
Pavia, Pavia, Italy, 27100
Actively Recruiting
4
UO di Sezione di Medicina Interna e Cardiovascolare, Ospedale Santa Maria della Misericordia, Perugia, Italia
Perugia, Perugia, Italy, 06129
Actively Recruiting
5
UO di Cardiologia 1, Azienda Ospedaliero Universitaria Pisana, Pisa, Italia
Pisa, Pisa, Italy, 56126
Actively Recruiting
6
UO di Cardiologia, Azienda Ospedaliera Ordine Mauriziano di Torino
Torino, Torino, Italy, 10128
Actively Recruiting
7
UOC di Cardiologia, Ospedali dell'Ovest Vicentino, Arzignano, IItalia
Arzignano, Vicenza, Italy, 36071
Actively Recruiting
Research Team
C
Claudio Bilato, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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