Actively Recruiting

Phase Not Applicable
Age: 7Years - 10Years
All Genders
Healthy Volunteers
NCT06631339

Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)

Led by National University of Singapore · Updated on 2025-09-23

396

Participants Needed

5

Research Sites

118 weeks

Total Duration

On this page

Sponsors

N

National University of Singapore

Lead Sponsor

T

Technical University of Munich

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to evaluate whether the optimization of daily exposure to light in primary school children can lead to better myopia prevention and control. The trial also aims to better understand the impact of light exposure on sleep and cognitive performance in children. This trial has 3 arms namely, (1) a technical intervention arm, (2) a digital intervention arm, and (3) a control arm. 1. technical intervention - which involves changing of classroom lighting in primary schools to ceiling lights that mimic the spectral composition of sunlight and fluctuates in intensity. Parents of children within that arm will have a sham smart-phone application (s-LightUP) 2. digital intervention - which involves standard classroom lighting and giving parents an interventional smart-phone application (i-LightUP) that will be coupled with their child's light and activity sensor (wrist worn device ). The interventional app will provide individually tailored recommendation based on their children's behaviour (data feedback that is collected from the light and activity monitoring watch). The interventional app would then send reminder prompts/notifications to encourage parents help their children achieve required amounts of myopia-preventive light quantum target set per day. 3. Standard care or control group which involves standard classroom lighting and parents having a sham smart-phone application (s-LightUP) Participants will: * be randomised to receive either no intervention (control group), technical intervention (light intervention that mimics sunlight) or digital intervention (parents having an app that syncs with child's light and activity sensor which will provide feedback to parents to encourage and recommends increment of outdoor activities and hours). * have their myopia progression monitored every 6 monthly and cognitive assessment done once every 3 months over a year. * wear the light and activity sensor watches throughout the 1-year study period as much as possible (minimum 1 week per month) except for wet water activities such as swimming, diving and showering for research data collection purpose.

CONDITIONS

Official Title

Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)

Who Can Participate

Age: 7Years - 10Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Parent or legal guardian has given written consent and child has given assent
  • Child is between 7 to 10 years old at the start of the study intervention
  • Child is studying in Primary 2 or Primary 3 during academic year 2025 or 2026
  • Visual acuity or best corrected visual acuity is Snellen 6/9 (LogMAR 0.2) or better in each eye
  • Normal eye pressure (not more than 21mmHg)
  • No eye conditions except for refractive error
  • No eye conditions affecting accuracy of eye exams
  • Child is in good general health without systemic diseases affecting eye health
Not Eligible

You will not qualify if you...

  • Previous or current myopia control treatments such as orthokeratology, atropine, or special lenses
  • Participation in other myopia prevention or control research trials
  • Systemic or neurological diseases affecting eye health or ability to undergo eye exams (e.g., cancer, epilepsy)
  • Any condition preventing adherence to the study protocol, including unwillingness to avoid myopia control treatments during the study

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 5 locations

1

National University of Singapore, Yong Loo Lin School of Medicine, Department of Ophthalmology, Eye N Brain Research Lab

Singapore, Singapore, 119276

Actively Recruiting

2

Marymount Convent School

Singapore, Singapore, 297754

Actively Recruiting

3

Bedok Green Primary School

Singapore, Singapore, 469317

Actively Recruiting

4

Westwood Primary School

Singapore, Singapore, 649188

Actively Recruiting

5

Wellington Primary School

Singapore, Singapore, 757702

Actively Recruiting

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Research Team

R

Raymond P. Najjar, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

3

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Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN) | DecenTrialz