Actively Recruiting
Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)
Led by National University of Singapore · Updated on 2025-09-23
396
Participants Needed
5
Research Sites
N/A
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
T
Technical University of Munich
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether optimizing daily light exposure in primary school children aged 7 to 10 can better prevent and control myopia. The study also aims to understand how light exposure affects children's sleep and cognitive performance, including impulse control, working memory, reaction time, and processing speed. This interventional trial involves three groups to compare different approaches to light exposure. The study includes three arms: a technical intervention with classroom lighting mimicking sunlight using fluctuating full-spectrum LEDs, a digital intervention where parents use a smartphone app synced to a child-worn light and activity sensor to encourage outdoor activities, and a control group with standard classroom lighting and a sham app. The interventions last for one academic year, during which children wear the light and activity sensor watches as much as possible, except during water activities. Participants will have their myopia progression monitored every 6 months using eye measurements such as cycloplegic auto-refraction, axial length, and choroidal thickness. Cognitive assessments occur every 3 months through tablet-based tasks in classrooms. Sleep quantity and efficiency are tracked continuously via wrist actigraphy for at least one week per month. Additional measures include retinal perfusion, corneal curvature and thickness, height, weight, and visual acuity. This comprehensive monitoring takes place throughout the one-year study period to assess the impact of light exposure interventions.
CONDITIONS
Brief Title
Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent from parent or legal guardian and child assent obtained
- Child is between 7 to 10 years old at the start of the study intervention
- Child is studying in Primary 2 or Primary 3 in the participating school(s) during academic year 2025 or 2026
- Visual acuity or best corrected visual acuity (BCVA) of LogMAR 0.2 or better (equivalent to Snellen 6/9 or better) in each eye
- Normal intraocular pressure (not more than 21mmHg)
- No ocular conditions except refractive error
- No ocular conditions affecting accuracy of eye exams
- Good general health with no significant systemic diseases affecting eye health
You will not qualify if you...
- Previous or ongoing myopia control treatments (e.g., orthokeratology, atropine, pirenzepine, myopia control lenses, light therapy)
- Participation in other myopia prevention or control research trials
- Systemic or neurologic diseases affecting eye health or making participant vulnerable to eye exams (e.g., cancer, epilepsy, Kawasaki disease)
- Any condition preventing adherence to the study protocol including unwillingness to avoid myopia control treatments during the study
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 academic year
Participants receive their assigned intervention during the school day for 1 academic year. This includes either technical classroom lighting refinement, a behavioral intervention using a smartphone application with light and activity sensors, or standard classroom lighting with a sham application.
Daily school day exposure throughout the academic year
Duration - 1 year
Participants attend scheduled assessments to monitor eye health, cognitive performance, and sleep over the 1-year study period.
Visits at Baseline, Month 3, Month 6, Month 9, and Month 12 with additional assessments every 3 or 6 months depending on the outcome measure
Trial Site Locations
Total: 5 locations
1
National University of Singapore, Yong Loo Lin School of Medicine, Department of Ophthalmology, Eye N Brain Research Lab
Singapore, Singapore, 119276
Actively Recruiting
2
Marymount Convent School
Singapore, Singapore, 297754
Actively Recruiting
3
Bedok Green Primary School
Singapore, Singapore, 469317
Actively Recruiting
4
Westwood Primary School
Singapore, Singapore, 649188
Actively Recruiting
5
Wellington Primary School
Singapore, Singapore, 757702
Actively Recruiting
Research Team
R
Raymond P. Najjar, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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