Study Comparing Pulsatile and Non-Pulsatile Blood Flow During Heart Surgery to Reduce Kidney Injury

What this Trial Is About

Researchers are evaluating the effectiveness of pulsatile blood flow during cardiopulmonary bypass to reduce the risk of acute kidney injury following cardiac surgery. Pulsatile flow mimics the natural pulse of a beating heart, compared to non-pulsatile flow which provides a constant blood flow. The study aims to compare these two methods to see if pulsatile flow improves clinical outcomes after surgery, particularly kidney health. Participants will be randomly assigned to receive either pulsatile or non-pulsatile blood flow during their cardiopulmonary bypass procedure. Both methods are standard care approaches used to maintain blood circulation while the heart is stopped during surgery. Pulsatile flow is generated by varying the pump rate to create pulses, while non-pulsatile flow uses a constant pump rate. The study does not involve masking or blinding. During the study, participants will be monitored from the time they enter the intensive care unit after surgery for up to seven days to assess kidney injury and other outcomes. Researchers will track acute kidney injury, blood transfusions, platelet counts, and mortality up to 30 days after surgery. The study will also observe the use and discontinuation of bypass modes and monitor safety. The total participation timeline includes the surgery and follow-up assessments in the hospital.

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury