Actively Recruiting
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
Led by University of Colorado, Denver · Updated on 2025-05-21
1100
Participants Needed
1
Research Sites
175 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
CONDITIONS
Official Title
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent
- Scheduled for elective cardiac surgery with cardiopulmonary bypass
You will not qualify if you...
- Emergency procedures
- Scheduled for heart or lung transplantation
- Scheduled for ventricular assist device implantation
- Use of the Medtronic Elongated Once-Piece Arterial Cannula
- Diagnosed with sepsis
- Diagnosed with delirium
- Experiencing hemodynamic instability (heart rate > 100 and systolic blood pressure < 90)
- Requiring mechanical circulatory support
- Requiring vasoactive medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
N
Nathan J Clendenen, MD,MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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