Effects of Dexamethasone on Nausea, Vomiting, and Inflammatory Indexes After Total Knee Arthroplasty.
Jiazheng Chen, Yizhen He, Ting Deng...
https://pubmed.ncbi.nlm.nih.gov/40803755Actively Recruiting
Age: 50Years - 80Years
All Genders
ID07442812
The Role of Dexamethasone in Total Knee Arthroplasty: Effects of Oral and Intravenous Administration on Early Postoperative Pain and Mobilization
Led by Haseki Training and Research Hospital · Updated on 2026-05-20
270
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how the timing and method of dexamethasone administration affect early recovery after primary total knee arthroplasty in adults aged 50 to 80 with knee osteoarthritis. The study focuses on comparing oral versus intravenous dexamethasone, or no dexamethasone, as given by surgeons in routine clinical care. The goal is to understand effects on pain, mobility, knee movement, inflammation, metabolic changes, opioid use, and nausea during early recovery. Participants receive dexamethasone according to their surgeon's usual protocol: either 8 mg preoperatively and 4 mg postoperatively given intravenously or orally, or no dexamethasone if not part of the routine care. All surgeries and postoperative care, including pain management and opioid use when needed, follow standard institutional procedures without any changes introduced by the study. During the early postoperative period, participants undergo regular assessments of pain using a visual analog scale every six hours for 48 hours, mobility tests daily, nausea scoring, knee range of motion, inflammation markers, blood sugar levels, and opioid consumption. Data is collected prospectively, and participants provide consent before enrollment. The study observes real-world outcomes without altering standard treatment and will analyze results to understand recovery differences.
CONDITIONS
Brief Title
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty
Who Can Participate
Age: 50Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 50 and 80 years
- Diagnosis of primary knee osteoarthritis (primary gonarthrosis)
- Scheduled for elective primary total knee arthroplasty
- ASA physical status I or II
- Ability to ambulate independently (with or without assistive devices) preoperatively
- Ability to understand study procedures and complete pain and functional assessments
- Provision of written informed consent
You will not qualify if you...
- Revision total knee arthroplasty
- History of knee joint infection
- Inflammatory arthritis (e.g., rheumatoid arthritis)
- Chronic systemic corticosteroid use
- Uncontrolled diabetes mellitus
- Known endocrine disorders affecting glucose metabolism
- Active infection at any site
- Known hypersensitivity to corticosteroids
- Severe hepatic, renal, or cardiac disease
- Neurological or musculoskeletal disorders affecting gait or balance
- Inability or unwillingness to comply with study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - Day of surgery to postoperative day 2
Participants undergo total knee arthroplasty with perioperative dexamethasone administration according to the routine protocol of the operating surgeon or receive no dexamethasone. Postoperative management follows standard institutional care including multimodal analgesia and clinical assessments.
Daily visits during hospital stay including surgery day and first 2 postoperative days
Post-operative Follow-up
Duration - Up to 2 days after surgery
Participants are monitored for early postoperative recovery including pain intensity, functional mobility, nausea and vomiting, opioid use, laboratory markers, and knee range of motion according to routine care protocols.
Daily assessments for 2 days post-surgery
Trial Site Locations
Total: 1 location
1
Sultangazi Haseki Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye), 34200
Actively Recruiting
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Research Team
A
Atahan Eryilmaz, Resident Physician
M
Mehmet Ersin, Associate Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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Published Research Related To This Trial
Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials.
Gildàsio S De Oliveira, Marcela D Almeida, Honorio T Benzon...
https://pubmed.ncbi.nlm.nih.gov/21799397Effect of Intravenous Dexamethasone on Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Shuang Liang, Manyu Xing, Shasha Jiang...
https://pubmed.ncbi.nlm.nih.gov/35322969Two doses of low-dose perioperative dexamethasone improve the clinical outcome after total knee arthroplasty: a randomized controlled study.
Bin Xu, Jun Ma, Qiang Huang...
https://pubmed.ncbi.nlm.nih.gov/28474088Preoperative dexamethasone for pain relief after total knee arthroplasty: A randomised controlled trial.
Timmy Chi Wing Chan, Chi Wai Cheung, Stanley Sau Ching Wong...
https://pubmed.ncbi.nlm.nih.gov/33105245