Oral Metformin Treatment for Melasma in Latin American Women Aged 21 and Older

What this Trial Is About

Researchers are evaluating if metformin can help reduce the dark patches of melasma in Latin American women. This clinical trial aims to determine whether taking metformin daily for three months improves melasma, by comparing two different doses to see if either dose helps with this skin condition. The study is sponsored by the University of Puerto Rico and focuses on adult women aged 21 years and older. Participants will take oral metformin tablets starting at 500 mg once daily for the first four weeks. If participants tolerate the medication well, their dose will increase to 500 mg twice daily for the remaining eight weeks. During the trial, participants are asked to avoid other melasma treatments and use sunscreen with SPF 30 or higher daily. The study involves two clinic visits one at the beginning and one at the end of the 12-week period. Throughout the study, researchers will monitor changes in the modified Melasma Area and Severity Index mMASI score from the start to week 12 to assess treatment impact. Participants will receive a phone call from the research team to check on their progress and any side effects. The total participation time spans three months, with evaluations at the start and conclusion of the treatment period.

Oral Metformin for Treating Melasma in Latin American Women