Comparing Oral and Intravenous Magnesium to Prevent Emergence Delirium in Children Having Adenotonsillectomy

What this Trial Is About

Researchers are evaluating the effects of oral versus intravenous magnesium on the incidence and severity of emergence delirium in children aged 4 to 7 years undergoing adenotonsillectomy with sevoflurane anesthesia. This study addresses the preventive value of magnesium using two different administration routes and explores its calming and analgesic properties that may reduce emergence delirium, a common postoperative complication in children. Participants are randomly assigned to one of three groups receiving oral magnesium syrup two hours before surgery, receiving intravenous magnesium sulfate after anesthesia induction, or receiving placebo treatments oral lemon juice and intravenous saline. The oral dose is 150 mg, while the IV dose is 30 mgkg magnesium sulfate given over 10 minutes after anesthesia induction but before surgery begins. During the study, children are monitored for emergence delirium incidence and severity for up to one hour after surgery. Additional assessments include postoperative pain, parental separation anxiety, mask acceptance, rescue medication usage, extubation time, negative behavior changes within 24 hours, and side effects. Safety and outcomes are closely tracked throughout this period to understand the comparative effects of the magnesium treatments.

Oral Versus Intravenous Magnesium on Emergence Delirium