What is this study trying to find out about bone diseases like osteoporosis and osteoarthritis?

This study aims to understand how different bone cells and genetic factors affect bone health in diseases like osteoporosis and osteoarthritis. Researchers will analyze bone and blood samples from patients undergoing orthopedic surgery to identify new targets for treatment. The study is led by Relation Therapeutics and focuses on improving knowledge of bone biology over the next ten years.

Who may be eligible for this bone health clinical trial?

Adults aged 18 to 110 who are undergoing certain orthopedic surgeries such as joint replacements or fracture repairs may be eligible. Participants must be able to give informed consent and should not have active cancer, bone infection, or bloodborne diseases. The study accepts all genders. Please review eligibility criteria for more details.

Is there any cost to participate in this bone health clinical trial?

Study-related care, including the collection of bone and blood samples and all trial visits, is provided at no cost. However, personal travel expenses and other costs may vary and are not guaranteed to be covered. Participants can expect their study-related procedures to be covered by the research team.

Actively Recruiting

Age: 18Years - 110Years

All Genders

ID05732870

OSTEOMICS Study to Identify Key Regulators of Bone Health in Patients Undergoing Orthopaedic Surgery Including Osteoporosis and Osteoarthritis

Led by Relation Therapeutics · Updated on 2024-02-23

2000

Participants Needed

Research Sites

261 weeks

Total Duration

AI-Summary

What this Trial Is About

Diseases affecting bone due to aging, such as osteoporosis and osteoarthritis, lead to reduced bone mass, strength, and joint health. Current non-surgical treatments mainly involve drugs that do not change the disease and often cause side effects. This research aims to better understand how bone cells work and affect bone health to find new treatment targets. The study will collect bone samples from patients undergoing various orthopedic surgeries to analyze bone biology, genetics, and environmental factors. Participants include patients having elective or urgent orthopedic surgeries like joint replacements, fracture repairs, or osteotomies. Bone tissue removed during surgery will be collected for analysis within four hours. Blood samples and questionnaires will also be collected shortly after surgery. The study uses advanced single-cell techniques to explore bone cell diversity and applies machine learning to analyze how genetic differences impact bone structure and quality. During the study, participants will provide surgical bone waste and blood samples within hours of their procedure. They will complete questionnaires within one week after surgery. Researchers will monitor bone and blood samples to identify molecular and genetic factors that influence bone health. The study plans to run over the next ten years, generating detailed data to help develop new therapies for bone diseases associated with aging.

CONDITIONS

Brief Title

OSTEOMICS: Identifying Regulators of Bone Homeostasis

Who Can Participate

Age: 18Years - 110Years

All Genders

Eligibility Criteria

You may qualify if you...

Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint including hip, knee, shoulder, wrist, elbow, and ankle
Patients with fractured neck of femur undergoing hemiarthroplasty, total hip arthroplasty, or other internal fixation procedure
Patients undergoing acute low-velocity or fragility fracture fixation surgery
Patients aged 18 to 110 years who are able to provide informed consent

You will not qualify if you...

Patients unable to provide informed consent
Patients with suspected or established underlying malignancy
Patients with suspected or established osteomyelitis
Patients with suspected or established bloodborne disease
Patients currently participating in a clinical trial involving an investigational medicinal product

Research Team

Jake Taylor-King, DPhil

Susan O'Connor

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