Actively Recruiting
OSTEOMICS: Identifying Regulators of Bone Homeostasis
Led by Relation Therapeutics · Updated on 2024-02-23
2000
Participants Needed
8
Research Sites
261 weeks
Total Duration
On this page
Sponsors
R
Relation Therapeutics
Lead Sponsor
H
Harley Street Specialist Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Diseases affecting bone due to aging, such as osteoporosis and osteoarthritis, lead to reduced bone mass, strength, and joint health. Current non-surgical treatments mainly involve drugs that do not change the disease and often cause side effects. This research aims to better understand how bone cells work and affect bone health to find new treatment targets. The study will collect bone samples from patients undergoing various orthopedic surgeries to analyze bone biology, genetics, and environmental factors. Participants include patients having elective or urgent orthopedic surgeries like joint replacements, fracture repairs, or osteotomies. Bone tissue removed during surgery will be collected for analysis within four hours. Blood samples and questionnaires will also be collected shortly after surgery. The study uses advanced single-cell techniques to explore bone cell diversity and applies machine learning to analyze how genetic differences impact bone structure and quality. During the study, participants will provide surgical bone waste and blood samples within hours of their procedure. They will complete questionnaires within one week after surgery. Researchers will monitor bone and blood samples to identify molecular and genetic factors that influence bone health. The study plans to run over the next ten years, generating detailed data to help develop new therapies for bone diseases associated with aging.
CONDITIONS
Brief Title
OSTEOMICS: Identifying Regulators of Bone Homeostasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint including hip, knee, shoulder, wrist, elbow, and ankle
- Patients with fractured neck of femur undergoing hemiarthroplasty, total hip arthroplasty, or other internal fixation procedure
- Patients undergoing acute low-velocity or fragility fracture fixation surgery
- Patients aged 18 to 110 years who are able to provide informed consent
You will not qualify if you...
- Patients unable to provide informed consent
- Patients with suspected or established underlying malignancy
- Patients with suspected or established osteomyelitis
- Patients with suspected or established bloodborne disease
- Patients currently participating in a clinical trial involving an investigational medicinal product
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants undergo relevant orthopaedic surgery where bone waste and blood samples are collected within 4 hours of resection.
1 surgery visit (in-person)
Trial Site Locations
Total: 8 locations
1
Harley Street Specialist Hospital
London, Greater London, United Kingdom, W1G 8HU
Active, Not Recruiting
2
Barts Health NHS Trust
London, United Kingdom
Actively Recruiting
3
Chase Farm Hospital
London, United Kingdom
Actively Recruiting
4
Fitzrovia Hospital/QASMC
London, United Kingdom
Actively Recruiting
5
King's College Hospital
London, United Kingdom
Not Yet Recruiting
6
Luton & Dunstable University Hospital
London, United Kingdom
Active, Not Recruiting
7
Royal National Orthopaedic Hospital NHS Trust
London, United Kingdom
Not Yet Recruiting
8
West Middlesex University Hospital
London, United Kingdom
Actively Recruiting
Research Team
J
Jake Taylor-King, DPhil
S
Susan O'Connor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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