Actively Recruiting
Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
Led by Mayo Clinic · Updated on 2026-04-23
30000
Participants Needed
7
Research Sites
255 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates individuals without pancreatic cancer, but who have been determined to be at higher-than-average lifetime risk of developing pancreatic cancer to help detect pancreatic cancer or other cancers at an earlier time when they might be more easily treated and cured.
CONDITIONS
Official Title
Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 or older with a strong family history of pancreatic cancer or related genetic mutations
- At least two relatives with pancreatic ductal adenocarcinoma (PDAC) on the same side of the family, with two affected first-degree relatives
- Known pathogenic or likely pathogenic mutation in genes such as CDKN2A/p16, STK11, or PRSS1
- One or more second-degree relatives with PDAC and known mutations in ATM, BRCA1, BRCA2, PALB2, Lynch syndrome genes, or TP53
- Age 18 years or older with pancreatic cysts meeting Fukuoka worrisome or high-risk criteria including obstructive jaundice, mural nodules, or duct dilation
You will not qualify if you...
- Unable to provide informed consent
- History of non-autologous bone marrow transplant or active blood cancers like leukemia or lymphoma
- Current or prior pancreatic ductal adenocarcinoma or total pancreatectomy
- Currently incarcerated
- Unable to speak or read English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
HonorHealth Research Institute
Scottsdale, Arizona, United States, 85258
Withdrawn
2
Piedmont Healthcare
Atlanta, Georgia, United States, 30309
Actively Recruiting
3
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61615
Actively Recruiting
4
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
5
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198-6805
Actively Recruiting
6
Oregon Health & Science University
Portland, Oregon, United States, 97201
Actively Recruiting
7
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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