Actively Recruiting
Pancreatic Cancer Detection Consortium Prospective Cohorts to Study High-Risk Individuals Without Pancreatic Cancer
Led by Mayo Clinic · Updated on 2026-06-01
30000
Participants Needed
9
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying individuals who do not have pancreatic cancer but are considered at higher-than-average lifetime risk of developing it. This observational study aims to create a group of participants with strong family histories, specific genetic mutations, or high-risk pancreatic cysts to better detect pancreatic or other cancers early when treatment may be more effective. The study is sponsored by the Mayo Clinic and focuses on collecting data and biospecimens to help identify biomarkers for pancreatic cancer risk. Participants will undergo blood sample collection, complete questionnaires, and have their medical records reviewed. Those with pancreatic cysts may also have cyst fluid collected during standard endoscopic ultrasound fine needle aspiration procedures. This process allows the study team to gather important biological samples and clinical information without additional invasive procedures beyond usual care. During the study, participants will be followed over time with repeated biospecimen collection and medical record reviews to track health outcomes. The researchers will develop a biobank of samples and data at enrollment and continue collecting information throughout the study period, which runs until November 2029. This ongoing follow-up helps monitor changes and supports research to validate early detection methods for pancreatic cancer.
CONDITIONS
Brief Title
Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- For family history or genetic mutation group: age 50 or older plus specific family history or genetic mutation criteria related to pancreatic cancer
- For pancreatic cyst group: age 18 or older with pancreatic cysts meeting Fukuoka worrisome or high-risk criteria
- Ability to provide informed consent
- Willingness to participate in blood sampling, questionnaires, and medical record review
You will not qualify if you...
- Unable to provide informed consent
- History of non-autologous bone marrow transplant or active blood cancer such as leukemia or lymphoma
- Current or prior diagnosis of pancreatic cancer or total pancreatectomy
- Current incarceration as a prison inmate
- Inability to speak or read English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to study completion (approximately 6 years)
Participants who undergo routine care are observed with blood sample collection, questionnaires, medical record reviews, and pancreatic cyst fluid collection during standard of care procedures.
Visits occur during routine endoscopic ultrasound procedures as needed
Trial Site Locations
Total: 9 locations
1
HonorHealth Research Institute
Scottsdale, Arizona, United States, 85258
Withdrawn
2
Piedmont Healthcare
Atlanta, Georgia, United States, 30309
Actively Recruiting
3
OSF Saint Francis Medical Center
Peoria, Illinois, United States, 61615
Actively Recruiting
4
The Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21231
Actively Recruiting
5
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
6
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
7
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198-6805
Actively Recruiting
8
Oregon Health & Science University
Portland, Oregon, United States, 97201
Actively Recruiting
9
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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