Actively Recruiting

Phase Not Applicable
Age: 20Years - 65Years
FEMALE
ID06082206

Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Mastectomy A Randomized Clinical Trial

Led by Assiut University · Updated on 2026-03-09

90

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Chronic pain following mastectomy is a common issue that significantly affects quality of life. This research evaluates the effects of two types of nerve blocks, the pectoral nerve block and the thoracic paravertebral block, on the occurrence of chronic pain after mastectomy. The study aims to clarify the relationship between acute postoperative pain and the development of chronic pain, focusing on women undergoing breast cancer surgery with possible lymph node dissection. Participants receive either a thoracic paravertebral block, where bupivacaine is injected between the costotransverse ligament and the parietal pleura, or a pectoral nerve block involving injections of bupivacaine between specific chest muscles. Both nerve blocks are guided by ultrasound to improve accuracy and reduce complications. The trial compares these two approaches for managing pain after surgery, with treatments administered during the operation. Throughout the study, participants will be monitored for the incidence of chronic pain at 3 and 6 months after surgery. Researchers will assess pain levels and related outcomes to understand the effectiveness and safety of each nerve block. The trial includes detailed follow-up to evaluate pain persistence and any associated complications, with the total study period lasting until March 2026.

CONDITIONS

Brief Title

Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Mastectomy:

Who Can Participate

Age: 20Years - 65Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Female patients aged 20 to 65 years
  • ASA grade I, II, or III
  • Body mass index (BMI) between 25 and 35
  • Undergoing mastectomy with or without axillary or sentinel lymph node dissection
  • Partial mastectomy with axillary lymph node dissection allowed
Not Eligible

You will not qualify if you...

  • Male sex
  • Patient refusal
  • Life expectancy less than 2 years
  • Active malignant disease
  • Pregnant or breastfeeding women
  • Bilateral surgery
  • Ipsilateral breast surgery within the past 3 years

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Surgery day

Participants receive either a thoracic paravertebral block or a pectoral nerve block during mastectomy surgery to manage postoperative pain.

1 visit (in-person) on the day of surgery

Post-operative Follow-up

Duration - 6 months

Participants are monitored for the incidence of chronic pain after surgery over 6 months.

Follow-up visits at 3 months and 6 months post-surgery

Trial Site Locations

Total: 1 location

1

Assiut governorate

Asyut, Egypt, 715715

Actively Recruiting

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Research Team

G

Ghada Abo Elfadl

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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