Actively Recruiting
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery
Led by University of Birmingham · Updated on 2025-02-19
12942
Participants Needed
37
Research Sites
289 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.
CONDITIONS
Official Title
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults and children aged 10 years or over
- Elective or emergency abdominal surgery via midline laparotomy with an anticipated abdominal incision of at least 5cm in length
- Written informed consent of patient (signature or a fingerprint)
You will not qualify if you...
- Patients undergoing caesarean section
- Patients with a documented or suspected allergy to chlorhexidine
- Patient unable to complete postoperative follow-up (not contactable after discharge)
- Previous enrolment in PENGUIN within the past 30 days
- American Society of Anesthesiologists (ASA) grade V patients (expected to die with or without surgery)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Hospital das Clinicas da Faculdade de Medicina de Botucatu - UNESP
Botucatu, São Paulo, Brazil
Actively Recruiting
2
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil
Actively Recruiting
3
Hospital Nossa Senhora da Conceicao
Porto Alegre, Brazil
Actively Recruiting
4
Hospital Universitario Professor Edgar Santos/Bahia
Salvador, Brazil
Actively Recruiting
5
Hospital Sao Jose - Criciuma/SC
São José, Brazil
Actively Recruiting
6
Homi Bhabha Cancer Hospital & Research Centre
Visakhapatnam, Andhra Pradesh, India, 530053
Actively Recruiting
7
Sher - i - Kashmir Institute of Medical Sciences
Srinagar, Jammu and Kashmir, India, 190011
Actively Recruiting
8
Chinchpada Christian Hospital
Chinchpāda, Maharashtra, India, 425417
Actively Recruiting
9
Kasturba Medical College Hospital, Manipal
Madhava Nagar, Manipal, Karnataka, India, 576104
Actively Recruiting
10
Government Medical College, Patiala
Patiāla, Punjab, India, 147001
Actively Recruiting
11
All India Institute of Medical Sciences, Bhubaneswar
Bhubaneswar, India, 751019
Actively Recruiting
12
Government Medial College & Hospital, Chandigarh
Chandigarh, India, 160047
Actively Recruiting
13
All India Institute of Medical Sciences, Jodhpur
Jodhpur, India, 342005
Actively Recruiting
14
Tata Medical Center
Kolkata, India, 700160
Actively Recruiting
15
Christian Medical College (CMC) & Hospital, Ludhiana
Ludhiana, India, 141008
Actively Recruiting
16
Madhepura Christian Hospital
Madhepura, India, 852113
Actively Recruiting
17
Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital
Mumbai, India, 400008
Actively Recruiting
18
Tata Memorial Hospital
Mumbai, India, 400012
Actively Recruiting
19
Maulana Azad Medical College
New Delhi, India, 110002
Actively Recruiting
20
All India Institute of Medical Sciences, Rishikesh
Rishikesh, India, 249203
Actively Recruiting
21
Christian Medical College & Hospital Vellore
Vellore, India, 632004
Actively Recruiting
22
Centro Médico Nacional de Occidente IMSS
Belisario Domínguez, Mexico, 44329
Actively Recruiting
23
Hospital Espanola Veracruz
Veracruz, Mexico, 91700
Actively Recruiting
24
University of Benin Teaching Hospital
Benin City, Nigeria, 300283
Actively Recruiting
25
University Of Abuja Teaching Hospital
Gwagwalada, Nigeria, 902101
Actively Recruiting
26
University College Hospital
Ibadan, Nigeria, 200285
Actively Recruiting
27
Obafemi Awolowo University Teaching Hospitals Complex
Ile-Ife, Nigeria, 233285
Actively Recruiting
28
University of Ilorin Teaching Hospital
Ilorin, Nigeria, 241102
Actively Recruiting
29
Ahmadu Bello University Teaching Hospital
Kaduna, Nigeria, 810105
Not Yet Recruiting
30
Aminu Kano Teaching Hospital
Kano, Nigeria, 700101
Not Yet Recruiting
31
Lagos State University Teaching Hospital
Lagos, Nigeria, 101233
Actively Recruiting
32
Lagos University Teaching Hospital
Lagos, Nigeria, 102215
Actively Recruiting
33
Nnamdi Azikiwe University Teaching Hospital
Nnewi, Nigeria, 435101
Not Yet Recruiting
34
Tygerberg Hospital
Cape Town, South Africa, 7505
Actively Recruiting
35
Groote Schuur Hospital
Cape Town, South Africa, 7925
Actively Recruiting
36
New Somerset Hospital
Cape Town, South Africa, 8001
Actively Recruiting
37
Paarl Provincial Hospital
Paarl, South Africa, 7646
Actively Recruiting
Research Team
D
Divya Kapoor
CONTACT
R
Rachel Lillywhite, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here