The revolving door of HIV care: Revising the service delivery cascade to achieve the UNAIDS 95-95-95 goals.
Peter Ehrenkranz, Sydney Rosen, Andrew Boulle...
https://pubmed.ncbi.nlm.nih.gov/34029346Actively Recruiting
Led by Centre for Infectious Disease Research in Zambia · Updated on 2025-06-13
3000
Participants Needed
2
Research Sites
17 weeks
Total Duration
Researchers are evaluating person-centred approaches to improve engagement and connection for people living with HIV who face challenges in maintaining viral suppression. The study focuses on populations in Zambia who are most affected by viremia, including pregnant and breastfeeding women, children, adolescents, and adults who are more than 30 days late for their hospital appointments. The research aims to identify barriers to sustained viral suppression and develop tailored strategies to address these obstacles in vulnerable groups. The study will take place over 36 months in 24 healthcare facilities across Lusaka and Central provinces in Zambia. Interventions will be co-created with stakeholders using Human Centred Design methods to develop a person-centred package that improves patient connection, rapport, and engagement in care. This package will be tested specifically among high-priority populations contributing to ongoing viremia. Participants will be monitored for updated estimates of viremia and care status over a two-year period. The study involves tracing patients who are lost to follow-up or have elevated viral loads, assessing their care status and viral suppression outcomes. Written informed consent will be obtained, and participants will be followed to evaluate the impact of the person-centred interventions on viral load suppression and sustained engagement in care.
CONDITIONS
PERSON-CENTERED APPROACHES TO VIREMIA: CONNECTION, RAPPORT, AND ENGAGEMENT STUDY
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Duration of the study follow-up period
Participants receive a person-centred package designed to connect them to service delivery, build rapport, and improve engagement in care to help achieve sustained viral load suppression.
Duration - 2 years
Participants are observed to assess updated estimates of viremia and care status over a 2-year period.
Total: 2 locations
1
Ministry of Health
Lusaka, Lusaka Province, Zambia, 10101
Not Yet Recruiting
2
Railway GRZ Urban Health Centre, Kafue District Health Hospital, Nangongwe OPD Urban Health Centre, Chawama 1st level hospital, Chipate 1st level hospital, Matero Reference Health Centre, Mtendere Health Centre, Lwiimba Rural Health Centre
Lusaka, Lusaka Province, Zambia, 10101
Actively Recruiting
K
Kombatende Sikombe
D
Dr Sikazwe
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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Peter Ehrenkranz, Sydney Rosen, Andrew Boulle...
https://pubmed.ncbi.nlm.nih.gov/34029346