The Feasibility of Personalized Hypoglycemia Outpatient Treatment for People Living With Type 2 Diabetes Mellitus

What this Trial Is About

This research aims to study personalized outpatient treatments for mild low blood sugar (hypoglycemia) in people living with type 2 diabetes. The trial evaluates two interventions designed to induce mild hypoglycemia, allowing participants to choose their preferred treatment and timing for blood sugar rechecks. It focuses on the feasibility of recruiting participants and understanding how personalized treatment choices affect hypoglycemia resolution. Participants can choose one or both interventions. The first involves riding a recumbent exercise bike at their desired speed until mild hypoglycemia develops, defined by a blood glucose level between 3.0 and 3.8 mmol/L. The second involves delaying food intake after taking their prescribed diabetes medications (sulfonylurea or insulin) under nurse supervision until mild hypoglycemia occurs. After hypoglycemia onset, participants select one of four carbohydrate treatment amounts (8, 16, 20, or 32 grams) and one of four blood glucose recheck times (15, 20, 25, or 30 minutes). During the study visit, participants will be monitored closely while exercising or after medication intake to detect mild hypoglycemia. Data on distance traveled on the bike and blood glucose levels will be recorded. Researchers will track feasibility of recruitment over 12 months and assess how well personalized treatment choices resolve hypoglycemia. The trial involves multiple visits with blood glucose testing and monitoring, with participant safety carefully observed throughout the study period.

Personalized Hypoglycemia Outpatient Treatment - a Feasibility Study