Actively Recruiting
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
Led by AstraZeneca · Updated on 2026-04-29
400
Participants Needed
204
Research Sites
169 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
D
Daiichi Sankyo
Collaborating Sponsor
AI-Summary
What this Trial Is About
TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd) compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2) positive advanced or metastatic lung cancer without actionable genomic alterations (AGA).
CONDITIONS
Official Title
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Stage IIIB, IIIC, or IV non-squamous NSCLC without actionable genomic alterations
- Negative tests for EGFR, ALK, ROS1, NTRK, BRAF, RET, MET exon 14 skipping, KRAS G12C, HER2, or other targetable mutations
- Positive for TROP2 protein by normalized membrane ratio
- Radiographic disease progression after most recent treatment for advanced or metastatic NSCLC
- Prior treatment with platinum-based chemotherapy plus anti-PD-1/PD-L1 antibody as one or two prior therapy lines
- Provide acceptable tumor tissue sample for TROP2 assessment
- At least one measurable lesion not previously irradiated, suitable for repeated imaging measurements
- ECOG performance status of 0 or 1
- Adequate bone marrow and organ function within 7 days before randomization
You will not qualify if you...
- Squamous, mixed NSCLC, or small cell lung cancer histology
- NSCLC eligible for only local therapy
- History of other primary malignancy except if treated curatively and no active disease for 3 years
- Spinal cord compression or brain metastases unless stable, asymptomatic, and off steroids or anticonvulsants for 7 days
- Clinically significant corneal disease
- Active or uncontrolled hepatitis B or C infection
- Known HIV infection not well controlled
- Uncontrolled infection requiring intravenous antibiotics, antivirals, or antifungals
- History or current interstitial lung disease or pneumonitis requiring steroids or suspected but not ruled out by imaging
- Severe lung function compromise as decided by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 204 locations
1
Research Site
Chandler, Arizona, United States, 85224
Actively Recruiting
2
Research Site
Gilbert, Arizona, United States, 85234
Actively Recruiting
3
Research Site
Goodyear, Arizona, United States, 85338
Actively Recruiting
4
Research Site
Duarte, California, United States, 91010
Actively Recruiting
5
Research Site
Irvine, California, United States, 92618
Actively Recruiting
6
Research Site
La Jolla, California, United States, 92093
Actively Recruiting
7
Research Site
Loma Linda, California, United States, 92350
Actively Recruiting
8
Research Site
Los Angeles, California, United States, 90095
Not Yet Recruiting
9
Research Site
San Diego, California, United States, 92123
Actively Recruiting
10
Research Site
Grand Junction, Colorado, United States, 81501
Actively Recruiting
11
Research Site
Wheat Ridge, Colorado, United States, 80033
Actively Recruiting
12
Research Site
Newark, Delaware, United States, 19713
Not Yet Recruiting
13
Research Site
Washington D.C., District of Columbia, United States, 20037
Not Yet Recruiting
14
Research Site
Fort Myers, Florida, United States, 33901
Not Yet Recruiting
15
Research Site
Jacksonville, Florida, United States, 32224
Actively Recruiting
16
Research Site
St. Petersburg, Florida, United States, 33709
Actively Recruiting
17
Research Site
Tampa, Florida, United States, 33612
Actively Recruiting
18
Research Site
West Palm Beach, Florida, United States, 33401
Not Yet Recruiting
19
Research Site
Marietta, Georgia, United States, 30060
Actively Recruiting
20
Research Site
Newnan, Georgia, United States, 30265
Actively Recruiting
21
Research Site
Chicago, Illinois, United States, 60612
Not Yet Recruiting
22
Research Site
Chicago, Illinois, United States, 60637
Actively Recruiting
23
Research Site
Niles, Illinois, United States, 60714
Actively Recruiting
24
Research Site
Zion, Illinois, United States, 60099
Actively Recruiting
25
Research Site
Louisville, Kentucky, United States, 40207
Actively Recruiting
26
Research Site
South Portland, Maine, United States, 04106
Not Yet Recruiting
27
Research Site
Baltimore, Maryland, United States, 21201
Actively Recruiting
28
Research Site
Brandywine, Maryland, United States, 20613
Actively Recruiting
29
Research Site
Boston, Massachusetts, United States, 02215
Actively Recruiting
30
Research Site
Detroit, Michigan, United States, 48202
Actively Recruiting
31
Research Site
Rochester, Minnesota, United States, 55905
Actively Recruiting
32
Research Site
Bridgeton, Missouri, United States, 63044
Actively Recruiting
33
Research Site
Columbia, Missouri, United States, 65212
Withdrawn
34
Research Site
Lincoln, Nebraska, United States, 68516
Actively Recruiting
35
Research Site
Albuquerque, New Mexico, United States, 87109
Actively Recruiting
36
Research Site
East Syracuse, New York, United States, 13057
Actively Recruiting
37
Research Site
Portland, Oregon, United States, 97239
Withdrawn
38
Research Site
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
39
Research Site
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
40
Research Site
Greenville, South Carolina, United States, 29607
Actively Recruiting
41
Research Site
Memphis, Tennessee, United States, 38120
Actively Recruiting
42
Research Site
Austin, Texas, United States, 78745
Actively Recruiting
43
Research Site
Denton, Texas, United States, 76201
Actively Recruiting
44
Research Site
Plano, Texas, United States, 75075
Actively Recruiting
45
Research Site
Charlottesville, Virginia, United States, 22908
Actively Recruiting
46
Research Site
Fairfax, Virginia, United States, 22031
Actively Recruiting
47
Research Site
Williamsburg, Virginia, United States, 23188
Actively Recruiting
48
Research Site
Tacoma, Washington, United States, 98405
Actively Recruiting
49
Research Site
Morgantown, West Virginia, United States, 26506
Actively Recruiting
50
Research Site
Eau Claire, Wisconsin, United States, 54703
Actively Recruiting
51
Research Site
Gosford, Australia, 2250
Actively Recruiting
52
Research Site
Kogarah, Australia, 2217
Actively Recruiting
53
Research Site
South Brisbane, Australia, 4101
Actively Recruiting
54
Research Site
St Albans, Australia, 3021
Actively Recruiting
55
Research Site
Wollongong, Australia, 2500
Actively Recruiting
56
Research Site
Graz, Austria, 8036
Not Yet Recruiting
57
Research Site
Linz, Austria, 4021
Not Yet Recruiting
58
Research Site
Rankweil, Austria, 6830
Actively Recruiting
59
Research Site
Vienna, Austria, 1140
Not Yet Recruiting
60
Research Site
Vienna, Austria, 1210
Actively Recruiting
61
Research Site
Hasselt, Belgium, 3500
Not Yet Recruiting
62
Research Site
La Louvière, Belgium, 7100
Not Yet Recruiting
63
Research Site
Libramont-Chevigny, Belgium, 6800
Not Yet Recruiting
64
Research Site
Namur, Belgium, 5000
Not Yet Recruiting
65
Research Site
Sint-Niklaas, Belgium, 9100
Not Yet Recruiting
66
Research Site
Porto Alegre, Brazil, 90610-000
Actively Recruiting
67
Research Site
Porto Alegre, Brazil, 91350-200
Actively Recruiting
68
Research Site
Salvador, Brazil, 40170-110
Actively Recruiting
69
Research Site
São Paulo, Brazil, 01246-000
Actively Recruiting
70
Research Site
São Paulo, Brazil, 01327-001
Actively Recruiting
71
Research Site
São Paulo, Brazil, 05652-900
Actively Recruiting
72
Research Site
Vancouver, British Columbia, Canada, VSZ 4E6
Actively Recruiting
73
Research Site
Moncton, New Brunswick, Canada, E1C 6Z8
Actively Recruiting
74
Research Site
Halifax, Nova Scotia, Canada, B3H 2Y9
Actively Recruiting
75
Research Site
Brampton, Ontario, Canada, L6R 3J7
Actively Recruiting
76
Research Site
Hamilton, Ontario, Canada, L8V 1C3
Actively Recruiting
77
Research Site
Toronto, Ontario, Canada, M5G 1X6
Actively Recruiting
78
Research Site
Beijing, China, 100034
Actively Recruiting
79
Research Site
Beijing, China, 100142
Actively Recruiting
80
Research Site
Beijing, China, 101149
Actively Recruiting
81
Research Site
Changchun, China, 130000
Actively Recruiting
82
Research Site
Changsha, China, 410013
Actively Recruiting
83
Research Site
Chengdu, China, 610041
Actively Recruiting
84
Research Site
Chengdu, China, 610072
Actively Recruiting
85
Research Site
Chongqing, China, 400030
Actively Recruiting
86
Research Site
Fuzhou, China, 350011
Actively Recruiting
87
Research Site
Guangzhou, China, 510080
Actively Recruiting
88
Research Site
Hangzhou, China, 310022
Actively Recruiting
89
Research Site
Harbin, China, 150081
Actively Recruiting
90
Research Site
Hefei, China, 230610
Actively Recruiting
91
Research Site
Jiamusi, China, 154007
Actively Recruiting
92
Research Site
Jinan, China, 250117
Actively Recruiting
93
Research Site
Nanchang, China, 330006
Actively Recruiting
94
Research Site
Nanjing, China, 2100008
Actively Recruiting
95
Research Site
Shanghai, China, 200030
Actively Recruiting
96
Research Site
Shanghai, China, 200032
Not Yet Recruiting
97
Research Site
Shanghai, China, 200433
Actively Recruiting
98
Research Site
Shantou, China, 515041
Actively Recruiting
99
Research Site
Shenyang, China, 110004
Actively Recruiting
100
Research Site
Tianjin, China, 300050
Actively Recruiting
101
Research Site
Wuhan, China, 430030
Withdrawn
102
Research Site
Wuhan, China, 430060
Actively Recruiting
103
Research Site
Xuzhou, China, 221009
Withdrawn
104
Research Site
Zhengzhou, China, 450008
Actively Recruiting
105
Research Site
Zhengzhou, China, 450052
Actively Recruiting
106
Research Site
Boulogne-Billancourt, France, 92104
Not Yet Recruiting
107
Research Site
Lyon, France, 69008
Not Yet Recruiting
108
Research Site
Marseille, France, 13915
Not Yet Recruiting
109
Research Site
Saint-Herblain, France, 44800
Not Yet Recruiting
110
Research Site
Toulouse, France, 31400
Not Yet Recruiting
111
Research Site
Bad Saarow, Germany, 15526
Not Yet Recruiting
112
Research Site
Bielefeld, Germany, 33611
Not Yet Recruiting
113
Research Site
Bonn, Germany, 53127
Not Yet Recruiting
114
Research Site
Cologne, Germany, 51109
Not Yet Recruiting
115
Research Site
Essen, Germany, 45147
Not Yet Recruiting
116
Research Site
Frankfurt, Germany, 60488
Not Yet Recruiting
117
Research Site
Freiburg im Breisgau, Germany, 79106
Withdrawn
118
Research Site
Gauting, Germany, 82131
Not Yet Recruiting
119
Research Site
Hamburg, Germany, 20251
Not Yet Recruiting
120
Research Site
Heidelberg, Germany, 69126
Not Yet Recruiting
121
Research Site
Krefeld, Germany, 47805
Not Yet Recruiting
122
Research Site
Minden, Germany, 32429
Not Yet Recruiting
123
Research Site
Oldenburg, Germany, 26121
Not Yet Recruiting
124
Research Site
Stuttgart, Germany, 70174
Not Yet Recruiting
125
Research Site
Troisdorf, Germany, 53840
Not Yet Recruiting
126
Research Site
Velbert, Germany, 42551
Not Yet Recruiting
127
Research Site
Budapest, Hungary, 1083
Not Yet Recruiting
128
Research Site
Budapest, Hungary, 1121
Not Yet Recruiting
129
Research Site
Budapest, Hungary, 1145
Not Yet Recruiting
130
Research Site
Debrecen, Hungary, 4032
Not Yet Recruiting
131
Research Site
Gyöngyös - Mátraháza, Hungary, 3200
Not Yet Recruiting
132
Research Site
Győr, Hungary, 9024
Not Yet Recruiting
133
Research Site
Gyula, Hungary, 5700
Not Yet Recruiting
134
Research Site
Kecskemét, Hungary, 6000
Not Yet Recruiting
135
Research Site
Szolnok, Hungary, 5000
Not Yet Recruiting
136
Research Site
Törökbálint, Hungary, 2045
Not Yet Recruiting
137
Research Site
Bangalore, India, 560027
Actively Recruiting
138
Research Site
Kolkata, India, 700016
Actively Recruiting
139
Research Site
Mumbai, India, 400012
Actively Recruiting
140
Research Site
Nashik, India, 422011
Actively Recruiting
141
Research Site
New Delhi, India, 11029
Actively Recruiting
142
Research Site
Milan, Italy, 20141
Not Yet Recruiting
143
Research Site
Milan, Italy, 20162
Not Yet Recruiting
144
Research Site
Monza, Italy, 20052
Not Yet Recruiting
145
Research Site
Orbassano, Italy, 10043
Not Yet Recruiting
146
Research Site
Padova, Italy, 35128
Not Yet Recruiting
147
Research Site
Rozzano, Italy, 20089
Not Yet Recruiting
148
Research Site
Chūōku, Japan, 104-0045
Actively Recruiting
149
Research Site
Fukuoka, Japan, 812-8582
Actively Recruiting
150
Research Site
Hiroshima, Japan, 734-8551
Actively Recruiting
151
Research Site
Iwakuni-shi, Japan, 740-8510
Actively Recruiting
152
Research Site
Kashiwa, Japan, 277-8577
Not Yet Recruiting
153
Research Site
Kawasaki-shi, Japan, 216-8511
Actively Recruiting
154
Research Site
Kyoto, Japan, 612-8555
Actively Recruiting
155
Research Site
Matsuyama, Japan, 791-0280
Actively Recruiting
156
Research Site
Nagoya, Japan, 464-8681
Actively Recruiting
157
Research Site
Niigata, Japan, 951-8566
Actively Recruiting
158
Research Site
Osaka, Japan, 541-8567
Actively Recruiting
159
Research Site
Osakasayama-shi, Japan, 589-8511
Actively Recruiting
160
Research Site
Sendai, Japan, 981-0914
Actively Recruiting
161
Research Site
Sunto-gun, Japan, 411-8777
Actively Recruiting
162
Research Site
Yokohama, Japan, 241-8515
Actively Recruiting
163
Research Site
Lodz, Poland, 93-338
Not Yet Recruiting
164
Research Site
Olsztyn, Poland, 10-357
Not Yet Recruiting
165
Research Site
Poznan, Poland, 60-569
Not Yet Recruiting
166
Research Site
Warsaw, Poland, 02-781
Not Yet Recruiting
167
Research Site
Goyang-si, South Korea, 10408
Actively Recruiting
168
Research Site
Incheon, South Korea, 21565
Actively Recruiting
169
Research Site
Seoul, South Korea, 03722
Actively Recruiting
170
Research Site
Seoul, South Korea, 06351
Actively Recruiting
171
Research Site
Seoul, South Korea, 5505
Actively Recruiting
172
Research Site
Suwon, South Korea, 16247
Actively Recruiting
173
Research Site
A Coruña, Spain, 15009
Not Yet Recruiting
174
Research Site
Barcelona, Spain, 8035
Not Yet Recruiting
175
Research Site
L'Hospitalet de Llobregat, Spain, 08908
Not Yet Recruiting
176
Research Site
Madrid, Spain, 28041
Not Yet Recruiting
177
Research Site
Málaga, Spain, 29010
Not Yet Recruiting
178
Research Site
Seville, Spain, 41009
Not Yet Recruiting
179
Research Site
Zaragoza, Spain, 50009
Not Yet Recruiting
180
Research Site
Kaohsiung City, Taiwan, 80756
Actively Recruiting
181
Research Site
Taichung, Taiwan, 40705
Actively Recruiting
182
Research Site
Tainan, Taiwan, 73657
Actively Recruiting
183
Research Site
Taipei, Taiwan, 10002
Actively Recruiting
184
Research Site
Taipei, Taiwan, 11217
Actively Recruiting
185
Research Site
Taipei, Taiwan, 11490
Actively Recruiting
186
Research Site
Taoyuan, Taiwan, 333
Actively Recruiting
187
Research Site
Bangkok, Thailand, 10210
Actively Recruiting
188
Research Site
Bangkok, Thailand, 10300
Actively Recruiting
189
Research Site
Bangkok, Thailand, 10700
Actively Recruiting
190
Research Site
Hat Yai, Thailand, 90110
Actively Recruiting
191
Research Site
Muang, Thailand, 50200
Actively Recruiting
192
Research Site
Ankara, Turkey (Türkiye), 06530
Actively Recruiting
193
Research Site
Istanbul, Turkey (Türkiye), 32098
Actively Recruiting
194
Research Site
Huddersfield, United Kingdom, HD3 3EA
Actively Recruiting
195
Research Site
London, United Kingdom, SE1 9RT
Not Yet Recruiting
196
Research Site
London, United Kingdom, SW10 9NH
Not Yet Recruiting
197
Research Site
London, United Kingdom, SW170QT
Actively Recruiting
198
Research Site
Maidstone, United Kingdom, ME16 9QQ
Withdrawn
199
Research Site
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
200
Research Site
Stoke-on-Trent, United Kingdom, ST4 6QG
Not Yet Recruiting
201
Research Site
Hanoi, Vietnam, 100000
Actively Recruiting
202
Research Site
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
203
Research Site
Ho Chi Minh City, Vietnam, 70000
Actively Recruiting
204
Research Site
Vinh, Vietnam, 460000
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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