Actively Recruiting
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in ICU Patients
Led by Shanghai Zhongshan Hospital · Updated on 2024-11-25
45
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Atelectasis, hypoxemia, and ineffective sputum clearance are common problems in ICU patients. Continuous High-Frequency Oscillation (CHFO) is often considered to have a protective effect on the lungs. CHFO provides effective gas exchange at supraphysiological frequencies while minimizing pressure fluctuations, producing tidal volumes smaller than dead space, and adjusting around a continuously expanding pressure to optimize end-expiratory lung volume (EELV), thereby improving lung function by achieving and maintaining lung recruitment. However, the physiological effects and safety of CHFO in awake critically ill patients are still lacking relevant research. The objective of this study is to evaluate the comfort, safety, and efficacy of CHFO in awake critically ill patients.
CONDITIONS
Official Title
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in ICU Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 and younger than 90 years
- Admitted to the ICU after December 1, 2024, who are alert, with a Glasgow Coma Scale (GCS) score of 15, normal comprehension, and able to communicate clearly through speech or writing
- Patients with atelectasis receiving oxygen therapy, high-flow oxygen, or ventilator support via tracheostomy
- Signed informed consent for MetaNeb treatment
You will not qualify if you...
- Refusal to participate in the proposed study
- Age less than 10 years
- Pregnancy
- Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour despite blood volume optimization, targeting mean blood pressure between 65 and 75 mmHg
- Participation in another trial within 30 days prior to eligibility
- Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation
- Pneumothorax or presence of a clear tracheoesophageal fistula
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
S
Shengyu Hao, PhD
CONTACT
Y
Yuxian Wang, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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