Actively Recruiting
Platelet Expression of Fcb3RIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
Led by University of California, Los Angeles · Updated on 2025-04-16
250
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
U
University of Pittsburgh Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to find out if people with higher levels of platelet Fcb3RIIa have a greater risk of having another ischemic stroke. It focuses on patients who have had a minor stroke or transient ischemic attack (TIA) caused by intracranial atherosclerotic disease (ICAD). Researchers want to understand how blood flow changes and platelet activity contribute to stroke recurrence by using imaging and blood tests. Participants will undergo blood sampling and magnetic resonance imaging (MRI) along with standard stroke cognitive tests when they join the study. They will have a follow-up visit after three months to check for any adverse events and repeat cognitive tests. After 12 months, another MRI and cognitive test will be done to evaluate their condition. Throughout the study, researchers will measure platelet Fcb3RIIa expression and wall shear stress from CT angiography using computational fluid dynamics. These measurements will help predict the risk of recurrent stroke over one year. Participants will be monitored with imaging and cognitive assessments to track any silent or clinical strokes, helping to develop a personalized risk model for stroke recurrence.
CONDITIONS
Brief Title
Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Stroke with symptoms lasting more than 24 hours and imaging evidence of acute ischemia in the affected vessel territory
- Minor stroke defined as NIHSS score less than 6
- Eligible transient ischemic attack (TIA) with specific imaging abnormalities or multiple stereotyped ischemic events
- Intracranial atherosclerotic disease affecting intracranial carotid, middle cerebral, vertebral, or basilar arteries
- Stenosis of 50-99% measured by CTA using WASID criteria
- Age 30 or older; ages 30-49 require established atherosclerotic disease elsewhere or two or more risk factors
- Ability to provide informed consent
You will not qualify if you...
- Stroke or TIA caused by other known conditions such as atrial fibrillation, mitral stenosis, mechanical valve, intracardiac thrombus, dilated cardiomyopathy, or proximal carotid/vertebral stenosis over 50%
- Contraindications to MRI including incompatible metallic implants or electronic devices
- Pregnancy or breastfeeding
- Morbid obesity or severe claustrophobia preventing MRI
- Other causes of stroke or TIA not related to intracranial atherosclerosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - At enrollment
Participants undergo blood sampling, magnetic resonance imaging (MRI), and stroke cognitive tests to collect baseline data related to their stroke and intracranial atherosclerotic disease.
1 visit (in-person)
Duration - 3 months after enrollment
Participants are monitored for adverse events and undergo a follow-up cognitive stroke test to assess their condition and recovery progress.
1 visit (in-person)
Duration - 12 months after enrollment
Participants undergo a follow-up MRI and cognitive stroke test to evaluate for recurrent silent ischemia and stroke at 12 months.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
D
David Liebeskind, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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