An evaluation of a low-cost platelet-rich plasma for osteoarthritis of the knee: A pilot study.
Daniel M Cushman, Luke A Johnson, Taylor Burnham...
https://pubmed.ncbi.nlm.nih.gov/40919485Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID07231471
Platelet Rich Plasma for Musculoskeletal Conditions
Led by University of Utah · Updated on 2026-05-06
10000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of Platelet-Rich Plasma (PRP) injections for treating various musculoskeletal (MSK) conditions, including osteoarthritis (OA) in multiple joints, tendinopathies, and plantar fasciitis. The study aims to track changes in pain, function, and patient satisfaction over a one-year period after receiving PRP, helping to build a detailed registry of treated patients. PRP has gained attention as a treatment with potential benefits and lower risks compared to corticosteroids, which are commonly used for these conditions. Participants who qualify and agree to join will receive a PRP injection prepared from their own blood. This involves drawing blood, spinning it in a centrifuge to concentrate platelets in the plasma, and then injecting this platelet-rich plasma into the affected area. The process keeps the blood sealed from air and uses specialized equipment for preparation. Follow-up surveys will be completed at multiple points: 2 weeks, 6 weeks, 3 months, 6 months, and 12 months after the injection. During the study, participants will undergo blood analysis to evaluate the PRP composition and complete various assessments measuring pain, function, and satisfaction. Outcome measures include the Visual Analog Score for pain, global satisfaction, and condition-specific tools such as the Western Ontario and McMaster Universities Arthritis Index for knees and other joint outcome questionnaires. The study will monitor these measures over 12 months, with a primary focus on pain at 6 months, to assess the effects of PRP treatment on MSK conditions.
CONDITIONS
Brief Title
Platelet Rich Plasma for Musculoskeletal Conditions
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Diagnosed with a musculoskeletal condition that may benefit from a PRP injection
- Have tried other conservative treatments without success
You will not qualify if you...
- Presence of active malignancy
- Active infection in the area planned for injection
- Known platelet disorders
- Presence of active systemic infections
- Current dialysis treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single treatment visit
Participants receive a Platelet-Rich Plasma (PRP) injection prepared from their own blood to treat their musculoskeletal condition.
1 visit (in-person) for blood collection and PRP injection
Follow-up
Duration - 12 months
Participants complete follow-up surveys to assess pain, function, and satisfaction after the PRP injection.
Surveys at 2 weeks, 6 weeks, 3 months, 6 months, and 12 months (remote or in-person)
Trial Site Locations
Total: 1 location
1
University of Utah Orthoaedic Center
Salt Lake City, Utah, United States, 84111-1334
Actively Recruiting
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Research Team
C
Christina Geisler, MS
J
Jamie Egbert, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Published Research Related To This Trial
Treating Knee Osteoarthritis With Platelet-Rich Plasma and Hyaluronic Acid Combination Therapy: A Systematic Review.
Michael R Baria, W Kelton Vasileff, James Borchers...
https://pubmed.ncbi.nlm.nih.gov/33831332Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up.
Andrejs Elksniņš-Finogejevs, Luis Vidal, Andrejs Peredistijs
https://pubmed.ncbi.nlm.nih.gov/32650801Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial.
Bijan Forogh, Elaheh Mianehsaz, Shervan Shoaee...
https://pubmed.ncbi.nlm.nih.gov/26173792Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial.
Nayana Joshi Jubert, Luciano Rodríguez, Maria Mercedes Reverté-Vinaixa...
https://pubmed.ncbi.nlm.nih.gov/28255569Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-analysis of 26 Randomized Controlled Trials.
Jixiang Tan, Hong Chen, Lin Zhao...
https://pubmed.ncbi.nlm.nih.gov/32679294Systemic effects of intra-articular corticosteroids.
George S Habib
https://pubmed.ncbi.nlm.nih.gov/19252817Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials.
Wen-Li Dai, Ai-Guo Zhou, Hua Zhang...
https://pubmed.ncbi.nlm.nih.gov/28012636Intra-articular injections of platelet-rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritis.
Jiabao Chu, Weifeng Duan, Ziqiang Yu...
https://pubmed.ncbi.nlm.nih.gov/35124707Effectiveness of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Clinical Trials.
Liu-Yan Nie, Kun Zhao, Jiaqi Ruan...
https://pubmed.ncbi.nlm.nih.gov/33718505