Actively Recruiting
Postprandial Effect of Isocaloric Challenge Meals Enriched With Indigenous Fruits and Vegetables on Glucose Metabolism in Individuals With Type 2 Diabetes in Wakiso District, Uganda
Led by KU Leuven · Updated on 2026-05-22
8
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how meals enriched with selected indigenous fruits and vegetables affect glucose and lipid levels in people living with type 2 diabetes in Wakiso district. The trial aims to find out if these challenge meals can improve blood sugar and fat levels. The study compares the effects of different meals to identify which indigenous fruit or vegetable has the strongest impact on lowering glucose and lipid levels. Participants will consume five different challenge meals over a 5-week period, with each meal enriched with one of three indigenous fruit or vegetable powders: Hibiscus sabdariffa, Solanum anguivi (Forest bitter berries), or Tamarindus indica (Tamarind). These powders were carefully prepared and tested for taste and nutrient content. Between each study visit, there will be a 5 to 7-day rest period to avoid carryover effects. Two additional reference challenge meals will also be given to assess variability within participants. During each visit, participants will consume the challenge meal and undergo tests over a 3-hour period to measure their blood glucose, lipid levels, plasma polyphenol metabolites, appetite, and meal palatability. These tests will be repeated at each of the five postprandial visits across the total 5-week study duration. Researchers will monitor changes in these measures to understand the effects of the meals. Participants will be randomly assigned to the different challenge meals and will not know which ingredients are in the meals they consume.
CONDITIONS
Brief Title
Postprandial Effect of Isocaloric Challenge Meals Enriched With Indigenous Fruits and Vegetables on Glucose Metabolism in Individuals With Type 2 Diabetes in Wakiso District, Uganda
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fasting blood sugar of 7 mmol/L or higher based on medical records
- Diagnosed with type 2 diabetes
- On diabetic treatment regimen for at least 6 months
- Plans to stay in the same location for the next 6 months
- Age between 30 and 60 years
You will not qualify if you...
- Taking dietary supplements
- Diagnosed with type 1 diabetes
- Tuberculosis co-infection
- Renal failure
- Liver cirrhosis
- Chronic pancreatitis
- Pregnancy or breastfeeding
- Regular participation in sports activities
- Participating in another clinical trial
- Receiving treatment for dyslipidaemia or hypertension
- Very low blood pressure (below 90/50 mmHg)
- Allergic reactions to test products
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 5 weeks
Participants consume one of the challenge meals enriched with indigenous fruit and vegetable powders or reference meals on each study day. Each test day lasts 3 hours with measurements performed during the visit. A 5 to 7-day washout period occurs between each postprandial study to prevent carryover effects.
5 postprandial visits over 5 weeks
Trial Site Locations
Total: 1 location
1
Kajjansi Health Centre IV
Wakiso, Uganda
Actively Recruiting
Research Team
T
Tonny Kiyimba, PhD
F
Fred Kigozi, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
5
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