Effect of Menstrual Cycle Phases on Postprandial Triglyceride Concentrations in Healthy Premenopausal Females: A Crossover Study

What this Trial Is About

Researchers are investigating how phases of the menstrual cycle affect post-meal triglyceride levels in healthy young women. The study aims to find out if triglyceride concentrations differ between the early follicular phase and the mid-luteal phase of the menstrual cycle. Participants will attend two experimental sessions where they will consume a high-fat meal representing 33% of their estimated daily energy needs, with 59% of calories from fat. After the meal, they will rest seated for six hours during each session, one in the early follicular phase and one in the mid-luteal phase. Participants will first undergo a screening session to confirm eligibility. During the study sessions, researchers will measure changes in various blood markers including total, buoyant, and denser triglycerides, non-esterified fatty acids, insulin, glucose, and beta-hydroxybutyrate over six hours. Additional outcomes such as hormone levels, energy expenditure, hunger, fullness, and oxidation rates will also be assessed. The study is designed to monitor these effects without randomization or blinding, with total participation spanning the screening and two experimental visits.

Postprandial Triglyceride Concentrations Across Menstrual Cycle Phases