A 6-Week Randomized, Double-Blind, Placebo-Controlled Virtual Study Evaluating an Olive Oil Extract on Knee Comfort and Function

What this Trial Is About

Researchers are evaluating whether an olive oil extract can improve knee pain, discomfort, and function in adults aged 40 to 75 years who have experienced knee discomfort for at least three months. This study aims to understand if daily consumption of the olive oil extract affects participants' perceptions of knee pain and their ability to perform daily activities. The study uses validated questionnaires and functional movement tests to assess changes over time. Participants are randomly assigned to receive either an olive oil extract dietary supplement capsule or a matching placebo capsule once daily with food for six weeks. The olive oil extract capsules contain standardized olive-derived bioactive compounds, including oleocanthal and oleacein, while the placebo capsules are designed to look and taste similar but do not contain these active compounds. The study includes an initial acute assessment on day one and ongoing monitoring throughout the six-week supplementation period. During the study, participants complete digital questionnaires on knee pain, stiffness, and function at scheduled times and perform two simple functional movement tests at home. They are encouraged to wear a compatible activity-tracking device to collect daily physical activity and sleep data. Saliva samples are collected at home at specific timepoints to measure inflammatory markers. Participants also record any use of pain medications and report any side effects. The main outcome measured is the change in knee pain, with additional assessments of stiffness, physical function, joint status, activity levels, and inflammatory markers over the six-week period.

Examining Olive Oil Extract on Knee Comfort and Function