Actively Recruiting
Precision Medicine for Every Child With Cancer
Led by Australian & New Zealand Children's Haematology/Oncology Group · Updated on 2024-07-17
3500
Participants Needed
11
Research Sites
260 weeks
Total Duration
On this page
Sponsors
A
Australian & New Zealand Children's Haematology/Oncology Group
Lead Sponsor
C
Children's Cancer Institute (CCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the use of precision medicine to improve outcomes for children and young adults with cancer in Australia and New Zealand. This research extends the ZERO platform to include all childhood cancer types and risk groups, focusing on how comprehensive molecular profiling and whole genome sequencing can help in diagnosis, risk assessment, and understanding genetic cancer predispositions. The study also builds on previous trials that showed benefits for high-risk patients and aims to evaluate these approaches in non-high-risk cases and rare tumors. Participants will have their tumor and normal tissue undergo detailed genetic testing, including whole genome sequencing, RNA sequencing, DNA methylation analysis, and targeted panel sequencing when needed. For high-risk cancers, additional preclinical drug screening and patient-derived xenograft testing may be performed. The study also explores the use of liquid biopsies to monitor tumor characteristics and treatment response. Various tumor types are included, such as central nervous system tumors, leukemias, lymphomas, sarcomas, and others, with personalized molecular analyses guiding therapy recommendations. During the study, participants and their families will provide consent and tumor samples for genetic testing. Researchers will monitor the usefulness of personalized therapy recommendations and genetic findings over five years. The study involves regular evaluations of clinical outcomes and the impact of precision medicine across different childhood cancer groups. Participants will be followed for at least five years to assess treatment results and the role of molecular tumor boards in guiding care.
CONDITIONS
Brief Title
Precision Medicine for Every Child With Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age under 18 years, with possible enrollment of patients aged 19 to 25 years with pediatric cancer after discussion
- Life expectancy greater than 6 weeks at time of enrollment
- Signed and dated informed consent for study participation from participant (if 18 or older) or parent/guardian (if under 18)
- Separate consent for germline genetic testing and return of germline results
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to several weeks depending on sample processing and analysis
Participants provide tumor and normal samples for comprehensive molecular profiling including whole genome sequencing, RNA sequencing, DNA methylation, targeted panel sequencing, and other genetic analyses to help understand their cancer.
1 to 2 visits depending on sample availability and procedures
Duration - Up to 5 years
Participants are observed over time to evaluate the utility of precision medicine approaches in diagnosis, risk stratification, and treatment recommendations for different childhood cancer types.
Periodic visits as determined by treating physicians
Trial Site Locations
Total: 11 locations
1
Women's and Children's Hospital
Adelaide, Australia
Actively Recruiting
2
Queensland Children's Hospital
Brisbane, Australia
Actively Recruiting
3
Royal Hobart Hospital
Hobart, Australia
Actively Recruiting
4
Monash Children's Hospital
Melbourne, Australia
Actively Recruiting
5
Royal Children's Hospital
Melbourne, Australia
Actively Recruiting
6
John Hunter Children's Hospital
Newcastle, Australia
Actively Recruiting
7
Perth Children's Hospital
Perth, Australia
Actively Recruiting
8
Sydney Children's Hospital, Randwick
Sydney, Australia
Actively Recruiting
9
The Children's Hospital at Westmead
Sydney, Australia
Actively Recruiting
10
Starship Children's Hospital
Auckland, Grafton, New Zealand, 1023
Actively Recruiting
11
Christchurch Hospital
Christchurch, New Zealand, 8011
Not Yet Recruiting
Research Team
N
National Study Coordinator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
13
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