Actively Recruiting
Towards an Integrated Care System for the Assistance of Patients With Chronic Diseases, Multimorbidity, Frailty, and Polypharmacy
Led by University of Pisa · Updated on 2025-12-02
110
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Pisa
Lead Sponsor
A
Azienda Ospedaliero, Universitaria Pisana
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating elderly non-autonomous patients who face a high risk of adverse health outcomes when admitted to the emergency department (ED). This study focuses on understanding whether biomarkers related to Alzheimer's disease and vascular dementia, specifically plasma phosphorylated tau 181 (ptau181) and cerebrovascular burden, can predict ED visits within six months. The research also considers the impact of patients' frailty but aims to assess these predictors independently of multidimensional clinical frailty. Participants in this observational study will have previously completed blood tests and brain imaging, such as MRI or CT scans, to assess cerebrovascular burden. At recruitment, plasma samples will be collected and analyzed using a specialized automated system to measure ptau181 levels. The study involves following participants for six months to monitor possible ED visits. During the study, researchers will collect and evaluate data on ED use, including the timing of these visits. Participants' cognitive status, frailty levels, and other health factors will be assessed through questionnaires and routine clinical information. The study aims to provide insights that could help improve risk stratification and care for elderly patients with reduced autonomy. The total observation period for each participant is six months from recruitment.
CONDITIONS
Brief Title
Predictors of Emergency Department Use in Frail Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fluency in Italian language
- Age 65 years or older
- Loss of autonomies of daily living as assessed by Katz or Lawton questionnaires
- Routine blood exams performed within 6 months prior to recruitment
- Head neuroimaging (MRI or CT) feasible for cerebrovascular burden assessment performed within 6 months prior to recruitment
You will not qualify if you...
- Withdrawal of informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At recruitment
Participants undergo blood collection and neuroimaging assessments to measure plasma phosphorylated Tau 181 levels and cerebrovascular burden for the evaluation of cognitive impairment and frailty.
1 visit (in-person)
Duration - 6 months
Participants are observed for emergency department use and related health outcomes over a 6-month period following recruitment.
Follow-up may occur as needed during the 6 months
Trial Site Locations
Total: 1 location
1
Azienda Ospedaliera Universitaria Pisana
Pisa, Pisa, Italy, 56126
Actively Recruiting
Research Team
F
Francesco Turco, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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