Actively Recruiting
Pregnancy Outcomes Prior to a Systemic Lupus Erythematosus Diagnosis
Led by University of Algiers · Updated on 2025-12-31
50
Participants Needed
2
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying pregnancies that occurred before the diagnosis of systemic lupus erythematosus (SLE) in women who were later diagnosed with this condition. This observational, retrospective cohort study aims to understand maternal and fetal outcomes as well as systemic signs of SLE present before or during pregnancy. The diagnosis of SLE is based on established criteria including the ACR 1997 and renal histological findings. The study collects information from medical records and patient interviews during medical visits. Data on all pregnancies before and after the diagnosis of SLE will be gathered, including obstetrical events and features such as anthropometric, biological, immunological, and histological data when available. The severity and activity of SLE after diagnosis will also be assessed using recommended tools. Participants will be evaluated from the beginning of each pregnancy until three months after childbirth. Researchers will measure the prevalence of obstetrical events before SLE diagnosis and compare pregnancy outcomes before and after diagnosis. The study involves reviewing medical histories and asking questions during visits to better understand how SLE affects pregnancies and disease severity over time.
CONDITIONS
Brief Title
Pregnancies Before the Diagnosis of Systemic Lupus Erythematosus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women of childbearing age with a history of at least one pregnancy
- Pregnancy occurred before the diagnosis of LES
- LES was diagnosed after at least one pregnancy
- Subject classified as having LES according to 1997 ACR or EULAR 2019 criteria
You will not qualify if you...
- LES was previously diagnosed before any conception
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies depending on participant history
Participants provide information about their pregnancies prior to the diagnosis of SLE through interviews and medical record review.
1 to 2 visits depending on pregnancy history
Duration - From diagnosis through 3 months after each childbirth
Participants are observed for disease activity and severity after the diagnosis of SLE, including assessment around each pregnancy and postpartum period.
Visits around each pregnancy and in the 3 months after childbirth
Trial Site Locations
Total: 2 locations
1
Department of internal medicine, Ain-Taya's teaching Public hospital
Aïn Taya, Algiers Province, Algeria, 16019
Active, Not Recruiting
2
Ain-Taya's Public Hospital
Algiers, Algeria, 16019
Actively Recruiting
Research Team
W
Wafia- Nadia Nibouche - Hattab, Professor in medicine
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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