Characterization of Immune Cell and Placental Cell Interaction in Pregnancy Disorders

What this Trial Is About

Researchers are studying how different immune cells interact with placental cells and how this interaction may lead to pregnancy complications, especially focusing on preeclampsia. The study aims to understand how uteroplacental syndrome develops into maternal symptoms in preeclampsia by examining immune cell subtypes that cause endothelial dysfunction and cardiovascular damage during pregnancy. This observational study includes healthy pregnant women as well as those diagnosed with preeclampsia, gestational hypertension, or gestational diabetes. Participants will be observed without receiving experimental treatments. The study focuses on comparing immune cell populations, particularly T cells, at the time of preeclampsia diagnosis to those in control pregnancies. Participants will undergo evaluations including flow cytometry to measure T cell populations during pregnancy. Researchers will collect data at the time of preeclampsia diagnosis and compare it with controls at the same gestational stage. The study is sponsored by Charite University in Berlin and includes women aged 18 to 45 years. The total participation duration varies by the timing of diagnosis and pregnancy progress.

Berlin-Brandenburg Pregnancy Cohort