Actively Recruiting
Changes in Cerebral Blood Flow Before and After Prone Position in Patients With ARDS Predict the Occurrence of Neurological Complications
Led by Sichuan Provincial People's Hospital · Updated on 2025-05-13
50
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This research focuses on patients with moderate to severe Acute Respiratory Distress Syndrome (ARDS) who require prone positioning treatment. The study aims to understand how changes in cerebral blood flow before and after prone positioning can predict neurological complications. It is an observational study collecting detailed medical records, demographic information, and clinical data from multiple hospitals in Sichuan Province between March 2025 and March 2026. Participants will undergo cerebral blood flow monitoring along with intracranial pressure and systemic hemodynamic assessments at specific time points: before prone positioning, 1 hour and 12 hours after prone ventilation, 1 hour after returning to the supine position, and again 7 days later. This monitoring helps evaluate the effects of prone positioning on brain blood flow in ARDS patients. Throughout the study, participants will be assessed using neuroimaging and biomarker tests from enrollment until two weeks after the end of treatment. Researchers will also track the incidence of delirium and cognitive function during this period. These evaluations aim to better predict neurological outcomes in patients undergoing prone ventilation for ARDS.
CONDITIONS
Brief Title
Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with moderate to severe ARDS requiring prone ventilation with PaO2/FiO2 <150 mmHg
- Expected mechanical ventilation duration longer than 48 hours
- Provided written informed consent
You will not qualify if you...
- Contraindications to prone positioning such as head and neck injuries, spinal instability, or severe intracranial hypertension
- Severe neurological diseases like cerebral hemorrhage, cerebral infarction, or brain tumors affecting cerebral hemodynamic monitoring
- Life-threatening ARDS
- Inability to undergo neurological assessment
- Poor or absent quality of imaging data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of prone ventilation as clinically indicated
Participants undergo prone ventilation for moderate to severe ARDS with cerebral blood flow, intracranial pressure, and systemic hemodynamic monitoring before, during, and after prone positioning.
Monitoring at 5 specific time points: before prone positioning (T0), 1 hour after prone ventilation (T1), 12 hours after prone ventilation (T2), 1 hour after returning to supine position (T3), and 7 days after returning to supine position (T4)
Duration - Up to 2 weeks after the end of treatment
Participants are observed for neurological complications through neuroimaging and biomarker detection up to 2 weeks after treatment ends.
Approximately 1 to 2 visits during follow-up
Trial Site Locations
Total: 1 location
1
Sichuan Provincial People's Hospital,
Chengdu, Sichuan, China, 610072
Actively Recruiting
Research Team
L
lingai Pan, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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