Monitoring Brain Blood Flow Changes in Adults with Moderate to Severe ARDS Receiving Prone Positioning to Predict Neurological Complications

What this Trial Is About

This research focuses on patients with moderate to severe Acute Respiratory Distress Syndrome ARDS who require prone positioning treatment. The study aims to understand how changes in cerebral blood flow before and after prone positioning can predict neurological complications. It is an observational study collecting detailed medical records, demographic information, and clinical data from multiple hospitals in Sichuan Province between March 2025 and March 2026. Participants will undergo cerebral blood flow monitoring along with intracranial pressure and systemic hemodynamic assessments at specific time points before prone positioning, 1 hour and 12 hours after prone ventilation, 1 hour after returning to the supine position, and again 7 days later. This monitoring helps evaluate the effects of prone positioning on brain blood flow in ARDS patients. Throughout the study, participants will be assessed using neuroimaging and biomarker tests from enrollment until two weeks after the end of treatment. Researchers will also track the incidence of delirium and cognitive function during this period. These evaluations aim to better predict neurological outcomes in patients undergoing prone ventilation for ARDS.

Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics