Early Detection of Gastric Cancer Using Fecal Helicobacter Pylori Genetic Testing and Risk Questionnaire in Adults Aged 40 and Older

What this Trial Is About

Researchers are conducting a prospective study to compare two methods for early detection of gastric cancer fecal Helicobacter pylori gastric cancer susceptibility testing and a gastric cancer risk questionnaire. The goal is to see if either method alone or combined can help diagnose gastric cancer earlier. This study involves adults aged 40 years and older from selected communities in Tongling City. Participants will provide stool samples for molecular testing to detect specific genetic markers linked to gastric cancer risk from H. pylori infection. They will also complete a detailed questionnaire about their gastric cancer risk. Those who test positive on either method will be referred for confirmatory diagnostic procedures, including fiberoptic endoscopy and biopsy. Individuals without a cancer diagnosis in the first year will enter an annual follow-up program. Residual stool samples will be stored for future biomarker research. Throughout the study, participants will undergo screening and risk assessment, followed by diagnostic workups if indicated. Researchers will monitor the accuracy of the testing methods over two years, measuring sensitivity, specificity, predictive values, and the rate of early gastric cancer diagnosis. The study will track participants health and collect data to evaluate how well these tools identify gastric cancer early, aiming to improve detection strategies.

Prospective Gastric Cancer Screening Using Helicobacter Pylori High-Risk Single Nucleotide Polymorphism Detection