Actively Recruiting
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes: PROMISE-Lung Study
Led by Duke University · Updated on 2026-05-11
2600
Participants Needed
19
Research Sites
N/A
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a large, observational study involving 2,600 adult lung transplant donors, candidates, and recipients to gather detailed clinical information, blood samples, and patient-reported outcomes. The study aims to create a comprehensive resource to explore how donor differences and medical practices affect transplant results and to identify blood markers linked to post-transplant complications. Participants include adults aged 18 and older who are either waiting for a lung transplant or have had one within the past 30 days. The study follows standard care protocols at each transplant center to minimize extra visits. Data collection includes clinical records, repeated blood samples (plasma, serum), DNA from recipients (and optionally donors), and patient questionnaires, all gathered during routine medical visits. Participants will be involved over several years with scheduled data extractions and specimen collections aligned with their usual care appointments. The research team will track the number of participants enrolled, completeness of key data, patient-reported outcomes collected, and specimens obtained. This approach supports future research to improve lung transplant management from listing through postoperative care.
CONDITIONS
Brief Title
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to understand and provide informed consent
- 18 years of age or older at the time of consent
- Anticipated listing or currently listed for single or bilateral cadaveric donor lung transplant, or received a lung transplant within 30 days
- Participants undergoing repeat lung transplantation or multi-organ transplantation are eligible if they meet other criteria
You will not qualify if you...
- Unwillingness of participant or legally authorized representative to provide informed consent or comply with study protocol
- Pregnancy or plans to become pregnant
- Medical problems or findings that may pose additional risks, interfere with compliance, or affect data quality as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 years
Participants who undergo routine care are observed with data and biospecimens collected at standard clinical visits to support future research on lung transplant management.
Data and specimen collection aligned with routine care visits over 3 years
Trial Site Locations
Total: 19 locations
1
University of California Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
2
University of California at San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
3
Stanford University Medical Center
Stanford, California, United States, 94305
Actively Recruiting
4
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
5
Johns Hopkins University
Baltimore, Maryland, United States, 21205
Actively Recruiting
6
Brigham and Womens Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
7
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
8
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
9
New York University
New York, New York, United States, 10016
Actively Recruiting
10
Columbia University
New York, New York, United States, 10032
Actively Recruiting
11
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
12
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
13
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15261
Actively Recruiting
14
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
15
Houston Methodist Hospital, Texas Medical Center
Houston, Texas, United States, 77030
Actively Recruiting
16
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
17
University of Washington
Seattle, Washington, United States, 98109
Actively Recruiting
18
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Actively Recruiting
19
University Health Network
Toronto, Canada
Actively Recruiting
Research Team
A
Allyn Damman
C
Carl Schuler, RN
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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