Prospective Registry Study of Esophageal Motility and Related Disorders Including GERD, Achalasia, and Other Esophageal Conditions At IRCCS San Raffaele Hospital

What this Trial Is About

Researchers are studying patients with upper digestive tract symptoms, especially those that may indicate conditions like Gastroesophageal Reflux Disease GERD, Barrett Esophagus, or various esophageal motility disorders such as achalasia and others. This observational study aims to create a detailed registry to better understand these digestive conditions by collecting clinical, endoscopic, radiologic, and physiological data. The research will help improve diagnosis and management of esophageal disorders by integrating information from multiple sources over time. The study collects data using specialized tests including High-Resolution Manometry, 24-hour esophageal pH-impedance monitoring, and Functional Lumen Imaging Probe assessments. These tests help profile esophageal motility and reflux issues in patients either new to treatment or after surgeries like anti-reflux procedures. Participants will be those referred to the Digestive Physiopathology Unit, and the registry gathers both retrospective and prospective data to support ongoing research. Participants will undergo standard care procedures including clinical evaluations, endoscopy, radiologic imaging, and validated questionnaires to assess symptom activity. Data collection spans several years, from 2026 to 2031, with the aim to track and analyze physiological, clinical, and imaging results. The study will monitor safety and disease progression while helping to shape future treatment approaches through long-term follow-up.

PRospective Registry of Esophageal Motility