Actively Recruiting
Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer
Led by Canadian Cancer Trials Group · Updated on 2026-05-12
320
Participants Needed
64
Research Sites
263 weeks
Total Duration
On this page
Sponsors
C
Canadian Cancer Trials Group
Lead Sponsor
A
Alliance for Clinical Trials in Oncology
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to answer the following question: Can the chance of lung cancer growing or spreading be lowered by adding targeted radiotherapy to the usual combination of drugs? This study is being done to find out if this approach is better or worse than the usual approach for lung cancer. The usual approach is defined as the care most people get for non-small cell lung cancer.
CONDITIONS
Official Title
Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Metastatic (stage IV) non-small cell lung cancer confirmed by imaging and pathology without driver mutations for targeted first-line therapy
- Limited progression on first-line immune checkpoint inhibitor (ICI) therapy with or without chemotherapy after at least 3 cycles
- All progressing sites can be safely treated with stereotactic body radiotherapy (SBRT) as determined by radiation oncology
- Stable brain metastases without cavitation or hemorrhage; asymptomatic and off corticosteroids for at least 1 week
- Eligible for approved standard first- or second-line systemic therapies
- 18 years of age or older
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
- Prior adjuvant/neoadjuvant/consolidation systemic therapy allowed if at least 6 months have passed before starting metastatic treatment
- Recovered to grade 1 or lower from prior systemic therapy toxicities
- Prior surgery for NSCLC allowed if at least 28 days have passed and wound healing is complete
- Prior external beam radiation allowed if at least 14 days have passed; re-treatment possible if safe
- Prior palliative non-stereotactic radiotherapy allowed if lesions are asymptomatic
- SBRT to start within 3 weeks of enrollment (for Arm 1)
- Able and willing to complete quality of life questionnaires in English, French, or Spanish
- Access to SOC ICI and chemotherapy drugs must be available
- Able to attend treatment and follow-up visits
- Use of highly effective contraception if of childbearing potential
You will not qualify if you...
- Large-cell neuroendocrine carcinoma, pulmonary carcinoid tumor, or mixed small and non-small cell lung cancer
- Presence of leptomeningeal disease
- Pregnancy
- Serious medical conditions contraindicating radiotherapy (e.g., scleroderma, Ataxia Telangiectasia, interstitial lung disease, severe liver dysfunction)
- Any condition deemed inappropriate for study by investigator
- Concurrent treatment with other anticancer therapies or investigational agents
- Live attenuated vaccine received within 30 days prior to enrollment
- Use of medications causing clinically relevant drug interactions or overlapping toxicities affecting safety or efficacy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 64 locations
1
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
2
City of Hope at Irvine Lennar
Irvine, California, United States, 92618
Actively Recruiting
3
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, United States, 81501
Actively Recruiting
4
Saint Luke's Cancer Institute - Boise
Boise, Idaho, United States, 83712
Actively Recruiting
5
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, United States, 83619
Actively Recruiting
6
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, United States, 83642
Actively Recruiting
7
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, United States, 83687
Actively Recruiting
8
Alton Memorial Hospital
Alton, Illinois, United States, 62002
Actively Recruiting
9
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
10
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Actively Recruiting
11
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States, 60115
Actively Recruiting
12
Crossroads Cancer Center
Effingham, Illinois, United States, 62401
Actively Recruiting
13
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States, 60134
Actively Recruiting
14
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States, 60026
Actively Recruiting
15
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States, 60030
Actively Recruiting
16
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States, 60045
Actively Recruiting
17
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, United States, 62269
Actively Recruiting
18
Northwestern Medicine Oak Brook
Oak Brook, Illinois, United States, 60523
Actively Recruiting
19
Northwestern Medicine Orland Park
Orland Park, Illinois, United States, 60462
Actively Recruiting
20
Memorial Hospital East
Shiloh, Illinois, United States, 62269
Actively Recruiting
21
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Actively Recruiting
22
Mercy Hospital
Cedar Rapids, Iowa, United States, 52403
Actively Recruiting
23
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
Actively Recruiting
24
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, United States, 50309
Actively Recruiting
25
Miller-Dwan Hospital
Duluth, Minnesota, United States, 55805
Actively Recruiting
26
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, United States, 56303
Actively Recruiting
27
Saint Francis Medical Center
Cape Girardeau, Missouri, United States, 63703
Actively Recruiting
28
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
29
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
30
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
31
Siteman Cancer Center-South County
St Louis, Missouri, United States, 63129
Actively Recruiting
32
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States, 63136
Actively Recruiting
33
Nebraska Medicine-Bellevue
Bellevue, Nebraska, United States, 68123
Actively Recruiting
34
Nebraska Medicine-Village Pointe
Omaha, Nebraska, United States, 68118
Actively Recruiting
35
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
36
Northwell Health/Center for Advanced Medicine
Lake Success, New York, United States, 11042
Actively Recruiting
37
Mount Sinai Chelsea
New York, New York, United States, 10011
Actively Recruiting
38
Mount Sinai West
New York, New York, United States, 10019
Actively Recruiting
39
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
40
Manhattan Eye Ear and Throat Hospital
New York, New York, United States, 10065
Actively Recruiting
41
Lenox Hill Hospital
New York, New York, United States, 10075
Actively Recruiting
42
Queens Cancer Center
Rego Park, New York, United States, 11374
Actively Recruiting
43
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
44
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
45
State University of New York Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
46
Montefiore Medical Center-Einstein Campus
The Bronx, New York, United States, 10461
Actively Recruiting
47
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
48
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Actively Recruiting
49
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
50
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
51
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Actively Recruiting
52
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, United States, 17837
Actively Recruiting
53
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania, United States, 17050
Actively Recruiting
54
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
55
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
56
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
Actively Recruiting
57
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
58
The Don and Sybil Harrington Cancer Center
Amarillo, Texas, United States, 79106
Actively Recruiting
59
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, United States, 23235
Actively Recruiting
60
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
61
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, United States, 54806
Actively Recruiting
62
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
63
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
64
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
P
Pierre-Olivier Gaudreau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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