Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study.
Peter Slodička, Přemysl Falt, Václav Ranc...
https://pubmed.ncbi.nlm.nih.gov/39603958Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID06964425
Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma
Led by University Hospital Olomouc · Updated on 2025-07-02
20
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
University Hospital Olomouc
Lead Sponsor
P
Palacky University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the use of Raman spectroscopy, an optical technique that analyzes scattered light to provide a molecular fingerprint of tissue, to improve the diagnosis of extrahepatic cholangiocarcinoma. This cancer is difficult to diagnose due to the limited effectiveness of imaging and tissue sampling methods. The study aims to develop a method for in vivo Raman spectroscopy during bile duct examination to enhance current diagnostic capabilities. During the procedure, a fiber-optic Raman probe is inserted through an endoscope during an endoscopic retrograde cholangiopancreatography (ERCP) session. The probe is positioned under fluoroscopic guidance within the bile duct tissue affected by cholangiocarcinoma. Raman spectroscopy measurements are taken 20 times per patient—10 times on malignant tissue and 10 times on healthy bile duct tissue. The collected data are analyzed by a specialist to identify differences in tissue characteristics. Participants provide informed consent and undergo the ERCP procedure with the Raman probe as part of their diagnostic evaluation. Researchers will compare the Raman spectra of malignant versus healthy bile duct tissue to assess diagnostic differences. The study includes safety and procedural monitoring, with the total participation duration aligning with the ERCP procedure timeline. Data collection and analysis aim to support improved diagnostic methods for this challenging cancer type.
CONDITIONS
Brief Title
Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Person older than 18 years
- Known diagnosis of extrahepatic cholangiocarcinoma
- Indicated for endoscopic retrograde cholangiopancreatography (ERCP)
You will not qualify if you...
- Disagreement with participation in the study
AI-Screening
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Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo endoscopic retrograde cholangiopancreatography (ERCP) where a fiber-optic Raman probe is inserted to measure Raman spectra of malignant and healthy bile duct tissue.
1 procedure visit (in-person)
Trial Site Locations
Total: 1 location
1
Peter Slodička
Olomouc, Olomouc Region, Czechia, 77900
Actively Recruiting
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Research Team
P
Peter Slodička, M.D.
V
Václav Ranc, Assoc. Prof.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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