Using Raman Spectroscopy During ERCP to Diagnose Extrahepatic Cholangiocarcinoma

What this Trial Is About

Researchers are investigating the use of Raman spectroscopy, an optical technique that analyzes scattered light to provide a molecular fingerprint of tissue, to improve the diagnosis of extrahepatic cholangiocarcinoma. This cancer is difficult to diagnose due to the limited effectiveness of imaging and tissue sampling methods. The study aims to develop a method for in vivo Raman spectroscopy during bile duct examination to enhance current diagnostic capabilities. During the procedure, a fiber-optic Raman probe is inserted through an endoscope during an endoscopic retrograde cholangiopancreatography ERCP session. The probe is positioned under fluoroscopic guidance within the bile duct tissue affected by cholangiocarcinoma. Raman spectroscopy measurements are taken 20 times per patient10 times on malignant tissue and 10 times on healthy bile duct tissue. The collected data are analyzed by a specialist to identify differences in tissue characteristics. Participants provide informed consent and undergo the ERCP procedure with the Raman probe as part of their diagnostic evaluation. Researchers will compare the Raman spectra of malignant versus healthy bile duct tissue to assess diagnostic differences. The study includes safety and procedural monitoring, with the total participation duration aligning with the ERCP procedure timeline. Data collection and analysis aim to support improved diagnostic methods for this challenging cancer type.

Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study