Digital Study Comparing Online Tools to Increase Nigerian Parents Intent to Vaccinate Girls Aged 9-14 Against HPV

What this Trial Is About

This research aims to assess whether various types of digital health communication can increase parents intention to vaccinate their daughters aged 9 to 14 years against human papillomavirus HPV in Nigeria. HPV vaccination is important for preventing cervical cancer, but vaccination rates remain low due to parental hesitancy, misinformation, and limited engagement with existing health materials. This trial is designed as a randomized controlled study focusing on scalable digital approaches. Participants, who are parents or primary caregivers of unvaccinated girls aged 9 to 14, will be randomly assigned to one of five groups. These groups receive different digital content a motivational interviewing-style chatbot, an interactive game to combat vaccine misinformation, short educational videos about HPV vaccination, standard infographics from a national health agency, or unrelated health content about menstruation. All content is delivered online, and participants complete baseline and follow-up surveys. During the study, parents will report their intention to vaccinate immediately and one week after viewing the assigned content, with additional follow-ups at six months to measure vaccine uptake and other knowledge and attitude outcomes. Researchers will evaluate changes in HPV vaccine knowledge, perceptions of safety, willingness to recommend vaccination, and actual vaccine uptake. The total study period extends to December 2026, with data collected digitally and analyzed under an intention-to-treat approach.

Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers