Study of Red Light Treatment Effects on Blood Flow in Peripheral Artery Disease Patients

What this Trial Is About

Researchers are investigating the effects of red light treatment on blood flow in people with peripheral artery disease. This study aims to measure changes in blood flow in the calf muscle gastrocnemius using a special ultrasound technique before and after exposure to 670 nm wavelength light. The study is designed to better understand how this light exposure may influence blood flow and nitric oxide levels in patients with this condition. Participants will receive a single 5-minute exposure of red light applied just above the calf muscle. Blood flow will be measured using an ultrasound contrast agent called octafluoropropane infused into the bloodstream. Blood samples will also be taken to measure nitric oxide metabolites before and after the light exposure. Most participants will have one study visit, but if needed, some may be asked to return for a second visit at least one week later to ensure consistent data collection. During the study visits, participants will have blood flow measured at baseline, during the 5 minutes of light exposure, and up to 1 minute after the light is turned off. Blood samples for nitric oxide metabolite measurement will be collected before and 1 minute after the light exposure. The study involves minimal risk and participation lasts for the duration of the visits, with careful monitoring of blood flow and biochemical markers related to vascular function.

Red Light Treatment in Peripheral Artery Disease