Actively Recruiting
Renal Cortical Shear Wave Elastography to Predict Kidney Function Recovery After Open Pyeloplasty for Unilateral Pediatric Ureteropelvic Junction Obstruction
Led by Beni-Suef University · Updated on 2026-06-03
84
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate whether renal cortical shear wave elastography can predict the recovery of kidney function after open pyeloplasty in children with unilateral primary ureteropelvic junction obstruction. This condition causes hydronephrosis and may impair kidney function, but surgery can potentially restore it. The study is a prospective observational cohort conducted at Beni-Suef University and focuses on children aged 6 months to 18 years. Participants will undergo standard open dismembered pyeloplasty surgery. Before surgery, children will have clinical assessments, lab tests, renal ultrasound, shear wave elastography to measure kidney stiffness, and renal isotope scans. After surgery, follow-up visits at 3 and 6 months will include clinical checks, ultrasound, shear wave elastography, and a repeat renal isotope scan to assess kidney function and drainage. Throughout the study, researchers will monitor changes in renal cortical shear wave elastography and compare these with isotope scan results to predict kidney function recovery. They will also track changes in ultrasound findings and renal function over time. The main focus is to see how well the change in elastography from before surgery to 3 months after predicts function at 6 months. The total participation lasts at least 6 months after surgery for each child.
CONDITIONS
Brief Title
Renal SWE as a Predictor After Pediatric Pyeloplasty for UPJO
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 6 months to 18 years
- Diagnosis of unilateral primary ureteropelvic junction obstruction
- Planned for open dismembered pyeloplasty
- Availability of preoperative renal ultrasonography, renal cortical shear wave elastography, and diuretic renography
- Written informed consent obtained from parent or legal guardian
You will not qualify if you...
- Bilateral ureteropelvic junction obstruction
- Secondary ureteropelvic junction obstruction
- Previous ipsilateral upper urinary tract surgery
- Major urinary tract anomalies affecting renal function (e.g., vesicoureteral reflux, megaureter, duplex system, posterior urethral valves, ectopic kidney)
- Active urinary tract infection at the time of assessment
- Known intrinsic renal parenchymal disease unrelated to obstruction
- Inability to obtain reliable shear wave elastography measurements
- Incomplete planned follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to the day of surgery
Participants undergo preoperative clinical assessment, laboratory investigations, renal ultrasonography, renal cortical shear wave elastography, and renal isotope assessment to evaluate kidney function and obstruction.
1 to 2 visits before surgery
Duration - Day of surgery
Participants undergo open dismembered pyeloplasty following standard surgical procedures to correct unilateral ureteropelvic junction obstruction.
1 in-person surgical visit
Duration - 6 months after surgery
Participants receive clinical assessments, renal ultrasonography, and renal cortical shear wave elastography at 3 and 6 months after surgery, including repeat renal isotope studies to monitor kidney function recovery.
Visits at 3 months and 6 months post-surgery
Trial Site Locations
Total: 1 location
1
Department of Urology- Beni-Suef University Hospitals
Banī Suwayf, Beni Suweif Governorate, Egypt
Actively Recruiting
Research Team
H
Hany F Badawy, MD
G
Ghada S Etman, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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