Actively Recruiting
Repeated Bout Effect i Neuromuscular Diseases
Led by Mads Peter Godtfeldt Stemmerik · Updated on 2025-04-06
50
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The repeated bout effect (RBE) refers to the adaptation whereby a single bout of eccentric exercise protects against muscle damage from subsequent eccentric bouts. This effect has been shown in many muscle groups using both serum biomarkers, muscle soreness and imaging techniques. Though the effect is well described in healthy, it has never been studied in patients with neuromuscular diseases (NMDs). In healthy, the RBE is only described using eccentric exercise, but unlike healthy persons, patients with NMDs can experience significant muscle damage with concentric exercise. This raises the question, if patients with NMDs could also show RBE when performing concentric exercise.
CONDITIONS
Official Title
Repeated Bout Effect i Neuromuscular Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Ability to complete the exercise challenge
- No other medical conditions that could affect result interpretation
- Molecular diagnosis of the specific neuromuscular condition or healthy control
- No active muscle injury on the test day (from exercise, seizures, trauma, etc.)
You will not qualify if you...
- Cardiac or pulmonary disease that prevents peak or strenuous exercise, defined as NYHA-class III-IV
- Veins too difficult to puncture for blood sampling, as judged by the investigator
- Severe muscle weakness preventing completion of the exercise test, as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Neuromuscular Research Unit, 3342
Copenhagen, Denmark, DK-2100
Actively Recruiting
Research Team
M
Mads Stemmerik, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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