Comparing Resin Infiltration and Self-Assembling Peptide P11-4 Treatments for White Spot Lesions in Children Aged 7 to 14

What this Trial Is About

This research aims to evaluate the effectiveness of two treatment methods for white spot lesions WSL on permanent teeth in patients aged 7 to 14 years. The study compares a self-assembling peptide called P11-4, used alone or combined with fluoride varnish, against resin infiltration. These treatments are being studied to improve the appearance and remineralization of these early tooth lesions, which are non-cavitated and located on smooth surfaces of the teeth. Participants will be randomly assigned to one of three treatment groups P11-4 peptide applied as a brush-on liquid, P11-4 combined with a fluoride varnish containing 500 ppm sodium fluoride, or resin infiltration that uses a resin infiltrant to mask lesions by changing their refractive index. The study will last six months, during which these treatments will be applied and their effects monitored. During the study, participants will undergo clinical examinations and photographic analysis to measure changes in lesion appearance and tooth remineralization. Tools like the International Caries Detection and Assessment System ICDAS and a Diagnodent Pen will be used to assess tooth health. Patient satisfaction with the treatments will also be measured using a 5-point faces scale. Safety and treatment progress will be monitored throughout the six-month period.

Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions