Comparing Resting Energy Use in Adults with Normal and Impaired Intestinal Function Including Intestinal Failure and Short Bowel Syndrome

What this Trial Is About

Researchers are studying resting energy expenditure in adults with different gastrointestinal functional statuses, including healthy adults and patients with intestinal failure. This prospective, comparative interventional study includes 92 participants aged 18 to 65 years, divided into two groups healthy adults with normal gastrointestinal function and patients with clinically confirmed intestinal failure, such as short bowel syndrome or other causes. The study aims to understand how resting energy expenditure varies between these groups and how it relates to body composition and inflammation. Participants undergo a single study visit lasting about 90 to 120 minutes. During this visit, resting energy expenditure is measured by indirect calorimetry after an overnight fast. Body composition is assessed using dual-energy X-ray absorptiometry and bioelectrical impedance analysis. Blood samples are collected to measure inflammatory markers. These assessments follow a standardized protocol and are performed outside routine clinical care. Throughout the visit, researchers collect data on resting energy expenditure, lean body mass, fat mass, phase angle, and inflammatory markers like C-reactive protein and various blood cell ratios. The primary outcome is the comparison of resting energy expenditure between healthy adults and those with intestinal failure. Secondary analyses explore associations with body composition and inflammation. The findings may help improve personalized nutritional management for patients with intestinal failure.

Resting Energy Expenditure by Gastrointestinal Functional Status