Actively Recruiting
Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Using High-resolution Magnetic Resonance Imaging, Imaging Histology, and Hemodynamics
Led by Zhujiang Hospital · Updated on 2025-07-28
1000
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the instability of intracranial multiple aneurysms (MIA) by establishing a prospective cohort based on an existing multicenter MIA database. The study aims to understand the risk factors and mechanisms behind aneurysm instability by using advanced methods such as high-resolution magnetic resonance imaging, hemodynamics analysis, ambulatory blood pressure monitoring, and imaging histology. Participants diagnosed with intracranial aneurysms suitable for endovascular intervention will undergo high-resolution MRI and other imaging techniques. The study will observe aneurysm features and assess changes over a one-year period. This observational study does not involve experimental treatments but focuses on collecting detailed data to analyze aneurysm behavior and outcomes. During the study, participants will be followed up for one year, with evaluations including high-resolution MRI features of aneurysms, postoperative modified Rankin Scale (mRS) scores, and aneurysm occlusion rates. Researchers will monitor clinical progress and imaging results to better understand aneurysm instability and potential risks. Participants will be asked to cooperate with imaging and follow-up visits as part of the research protocol.
CONDITIONS
Brief Title
Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Based on High-resolution Magnetic Resonance, Imaging Histology and Hemodynamics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years, male or infertile female
- Diagnosed with intracranial aneurysm by CTA, MRA, or DSA
- Suitable for endovascular intervention treatment
- Able to understand the study purpose and provide informed consent
- Willing to undergo high-resolution magnetic resonance imaging
- Willing to cooperate with follow-up and evaluations according to the study protocol
You will not qualify if you...
- Presence of arteriovenous malformation, Moyamoya disease, or dural arteriovenous fistula related aneurysms
- Contraindications to high-resolution magnetic resonance imaging
- Participation in other clinical trials involving drugs or medical devices
- Severe underlying diseases or poor clinical condition preventing general anesthesia surgery
- Poor compliance or inability to cooperate with follow-up
- History of severe allergy to contrast agents
- Life expectancy less than 2 years
- Women who are breastfeeding or planning pregnancy during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants undergo high-resolution magnetic resonance imaging and other imaging assessments to evaluate intracranial multiple aneurysm instability.
Periodic imaging visits over 1 year
Duration - Up to 1 year
Participants are monitored to assess postoperative outcomes including neurological function and aneurysm occlusion.
Follow-up visits over 1 year
Trial Site Locations
Total: 2 locations
1
Zhujiang Hospital
Guangzhou, Guangdong, China
Actively Recruiting
2
Southern medical university, zhujiang hospital
Guangzhou, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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