Actively Recruiting
School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions
Led by Thomas Pilgrim · Updated on 2026-01-20
6000
Participants Needed
2
Research Sites
163 weeks
Total Duration
On this page
Sponsors
T
Thomas Pilgrim
Lead Sponsor
C
Centre for Infectious Disease Research in Zambia (CIDRZ)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
CONDITIONS
Official Title
School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 5-16 years
You will not qualify if you...
- Children or primary caregivers who do not provide informed consent to participate
- Children not attending one of the selected schools
AI-Screening
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Trial Site Locations
Total: 2 locations
1
National Academy od Medical Sciences
Kathmandu, Nepal
Actively Recruiting
2
Centre of Infectious Disease Research
Lusaka, Zambia
Actively Recruiting
Research Team
T
Thomas Pilgrim Bern University Hospital, Bern, Switzerland
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
PREVENTION
Number of Arms
2
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