The global burden of group A streptococcal diseases.
Jonathan R Carapetis, Andrew C Steer, E Kim Mulholland...
https://pubmed.ncbi.nlm.nih.gov/16253886Actively Recruiting
Phase Not Applicable
Age: 5Years - 16Years
All Genders
Healthy Volunteers
ID05504928
Effectiveness of a School-centered Primary and Secondary Prevention Program on Prevalence of Latent Rheumatic Heart Disease
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2022-08-17
2300
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate how effective a school-centered program is at preventing latent rheumatic heart disease among schoolchildren in Nepal. It also investigates how socioeconomic and environmental factors influence the development and progression of this disease. Rheumatic heart disease is a serious condition affecting many children worldwide, especially in regions where group A beta-hemolytic streptococcal (GAHBS) infections are common, which can lead to acute rheumatic fever and heart damage. The study involves implementing a dedicated school nurse program at Tulsi Secondary Boarding School, focusing on assessing, intervening, and following up on cases of GAHBS pharyngitis. This program also facilitates secondary antibiotic prevention for children identified with latent rheumatic heart disease through echocardiography screening. The program is designed to provide timely detection and treatment to reduce the disease burden through primary and secondary prevention efforts. Participants, children aged 5 to 16 years attending the school, will undergo echocardiography before the program starts and again two and four years after implementation to measure the prevalence of latent rheumatic heart disease. Researchers will collect sociodemographic information through interviews and monitor outcomes such as GAHBS pharyngitis, acute rheumatic fever, and adverse reactions to penicillin. This longitudinal approach aims to assess the program's impact on disease prevalence and identify factors related to disease progression over a four-year period.
CONDITIONS
Brief Title
Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease
Who Can Participate
Age: 5Years - 16Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 5-16 years
- Attending Tulsi Secondary Boarding School in Tulsipur, Nepal.
You will not qualify if you...
- Children or primary caregivers not providing informed consent to participate
- Children not attending Tulsi Secondary Boarding School in Tulsipur.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - 4 years
Participants receive health care through a dedicated school nurse program that assesses, intervenes, and follows up on group A β-hemolytic streptococcal pharyngitis and facilitates secondary antibiotic prophylaxis for latent rheumatic heart disease.
Periodic visits coordinated by the school nurse as needed
Long-term Monitoring
Duration - 4 years
Participants are monitored over four years with echocardiography assessments before and two and four years after program implementation to evaluate the prevalence of latent rheumatic heart disease and related outcomes.
3 echocardiography assessments (baseline, 2 years, 4 years)
Trial Site Locations
Total: 1 location
1
Tulsi Secondary Boarding School
Tulsi̇̄pur, Nepal, 22412
Actively Recruiting
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Research Team
T
Thomas Pilgrim, Prof. Dr.
K
Krishna Agrawal, Prof. Dr.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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Published Research Related To This Trial
Rheumatic heart disease.
Eloi Marijon, Mariana Mirabel, David S Celermajer...
https://pubmed.ncbi.nlm.nih.gov/22405798Global, Regional, and National Burden of Rheumatic Heart Disease, 1990-2015.
David A Watkins, Catherine O Johnson, Samantha M Colquhoun...
https://pubmed.ncbi.nlm.nih.gov/28834488The incidence of sore throat and group A streptococcal pharyngitis in children at high risk of developing acute rheumatic fever: A systematic review and meta-analysis.
Sarah Pearce, Asha C Bowen, Mark E Engel...
https://pubmed.ncbi.nlm.nih.gov/33206687