Screening, Evaluation, and Assessment Protocol for Substance Use Disorder Research at NIDA Intramural Research Program

What this Trial Is About

Researchers are studying people with and without alcohol and substance use disorders (ASUD) to better understand why some use drugs, stop using them, avoid addiction, or never use them at all. This observational study is conducted by the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) and aims to improve knowledge and develop treatments for ASUD. It focuses on evaluating participants to determine their eligibility for other ongoing research studies at NIDA. Participants will undergo a thorough screening and evaluation process lasting up to 8 hours, which may be split across multiple days depending on individual interest and study requirements. The assessments include physical exams, various biological tests (blood, saliva, urine, breath), heart function tests, smell tests, cognitive and mental health evaluations, questionnaires about substance use and medical history, and mock MRI scans. This protocol serves as the initial step to identify individuals eligible for further NIDA research studies. During the study, participants will complete one or more visits for screening and evaluation. Researchers will collect detailed data on substance use, mental and physical health, and cognitive function through tests and questionnaires. This data will be used to create a registry of potential research participants and to support future analyses aimed at understanding addiction, abstinence, and related outcomes. The study allows participation of adults aged 18 to 99 years and includes people with current, past, or no history of substance use disorders.

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP