Screening and Evaluation Study for People With or Without Substance Use Disorders at NIDA IRP

What this Trial Is About

Researchers are evaluating the screening, evaluation, and assessment SEA process used by the National Institute on Drug Abuse NIDA Intramural Research Program IRP to understand alcohol and substance use disorders ASUD, including people with and without these disorders. The goal is to learn why some people use drugs, stop using, avoid addiction, or never use drugs, and to support the development of treatments for ASUD. This observational study screens adults aged 18 to 99 years who may currently use, formerly used, or never used substances such as nicotine, alcohol, opioids, or cocaine. Participants undergo a comprehensive screening visit lasting up to 8 hours, which may be split across multiple days depending on individual interests and study requirements. The screening includes tests such as physical exams, blood, saliva, urine, breath samples for alcohol and carbon monoxide, heart function tests, smell tests, cognitive assessments, mental health evaluations, mock MRI scans, and detailed questionnaires about substance use, mental health, medical history, and life experiences. This screening helps determine eligibility for other ongoing NIDA IRP clinical research protocols. During the study, participants complete one or more visits for clinical and general evaluations. Data collected help create a registry of potential candidates for future studies and support hypothesis-driven and exploratory research into substance use and addiction. The primary outcome is the assessment of eligibility for other NIDA protocols. Participation involves detailed assessments aiming to understand substance use behaviors and related health effects, with no active treatment administered in this observational protocol.

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP