Actively Recruiting
SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA)
Led by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Updated on 2026-03-30
500
Participants Needed
1
Research Sites
387 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. Although increasingly detected, a number of aspects including the pathophysiology, the clinical and neuroradiological phenotype and the disease course are still under investigation. The incomplete knowledge of the disease limits the implementation of evidence based guidelines on patient's clinical management and the development of treatments able to prevent or reduce disease progression. The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian multicentre cohort study aimed at better defining the disease natural history and identifying clinical and neuroradiological markers of disease progression. By a multidisciplinary approach and the collection of a large and well phenotyped series and biorepository of CAA patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA pathophysiological mechanisms.
CONDITIONS
Official Title
SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients aged 55 years or older (except genetic cases) referred to participating centers
- Diagnosis of possible, probable, or definite symptomatic or asymptomatic CAA based on modified Boston neuroradiological criteria
- At least one brain MRI scan performed (mandatory for inclusion)
You will not qualify if you...
- Other causes of brain hemorrhage such as brain tumors, arteriovenous malformations, aneurysms, or cavernous angiomas
- Contraindications to brain MRI
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UOC Neurologia 5
Milan, Milano, Italy, 20133
Actively Recruiting
Research Team
A
Anna Bersano, MD, Phd
CONTACT
R
Renato Mantegazza, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here